back to 2012, vol. 18, b. 1
Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2012, vol. 18, book 1
Subject Collection: Medicine
Page: 203 - 205
DOI: 10.5272/jimab.2012181.203
Published online: 07 February 2012

J of IMAB 2011; 17(1):203-205
Nadezhda S. Deleva, Alexandra J. Tzoukeva, Ara G. Kaprelyan, Kalina V. Drenska.
Department of Neurology, Medical University - Varna, Bulgaria

An association of MS with different anaemic syndromes, most often pernicious and Vit. B12 deficiency anaemia has been reported in the literature. Accordingly, the coincidence of anaemia with MS has been considered to impact seriously on clinical presentation, therapeutic strategy and patient´s quality of life.
Objective: To perform a retrospective analysis of 18 cases with anaemic syndrome as a factor of comorbidity in patients with MS.
Material and methods: 18 MS patients (15 women and 3 men) with RRMS (13), PPMS (2), and SPMS (3) diagnosed according to McDonald criteria were included in the present study. Average age was 36.4±8.5 (22-42) years, average disease duration 10.6±6.8 (4-18) years and means EDSS - 3.5±2.5 points (2-6). All individuals underwent clinical, MRI and hematological examinations.
Results: The study group included patients with pernicious (n=8), Vitamin B12 (n=6), and iron (n=3) deficiency anaemia, as well as with  β-thalassemia (n=1). In 12 patients anaemic syndrome proceeded MS and in 6 evolved during the course of the desease.
Conclusion: Our own notices and literature review suggests a possible causative relation between MS and anaemic syndrome. The role of this coincidence on clinical presentation, necessity of additional treatment, and patient´s quality of life is discussed.

Key words: MS, vitamin B 12 deficiency, pernicious anaemia, iron deficiency anaemia.

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Please cite this article as: Deleva NS, Tzoukeva AJ, Kaprelyan AG, Drenska KV. MULTIPLE SCLEROSIS ASSOCIATED WITH ANAEMIC SYNDROME: A RETROSPECTIVE ANALYSIS AND LITERATURE REVIEW. J of IMAB. 2012; 18(1):203-205. DOI: 10.5272/jimab.2012181.203.

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Accepted for publication: 08 December 2011
Issue published online: 07 February 2012

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