Title Page & Editorial Board

back to 2013, vol. 19, b. 3
Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2013, vol. 19, book 3;
Subject Collection: Medicine
Page: 438-441
DOI: 10.5272/jimab.2013193.438
Published online: 22 July 2013

J of IMAB. 2013 Jul-Dec;19(3):438-441;
Ivan N. Dimitrov 1Corresponding Autor, Ara G. Kaprelyan, Borislav Ivanov,
First Clinic of Neurology, "St. Marina" University Hospital, Varna, Bulgaria.

The development of sophisticated magnetic resonance imaging techniques and software for medical imaging processing and analysis has led to a significant progress in multiple sclerosis research and clinical care. The measurement of brain volumes provides a quantitative representation of damage, thus facilitating the objective follow-up process. The parameters obtained, though not being used routinely in clinical practice, are more and more often applied in clinical studies. The amount of whole brain and regional atrophy, estimated from serial scans, is considered important not only for disease progression, but also for cognitive dysfunction which is common in multiple sclerosis. In this paper we describe a volumetric study of two magnetic resonance scans of a patient with relapsing-remitting multiple sclerosis, performed 16 months one after the other, and analyzed using FSL SIENA software. Analysis demonstrated brain volume reduction of 1.7% between the two scans. We discuss the advantages of the method and its possible clinical applications.

Key words: Brain Volume; Brain Atrophy; Magnetic Resonance Imaging (MRI); Multiple Sclerosis;

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Please cite this article as:
Dimitrov IN, Kaprelyan AG, Ivanov B. A Case Study of Brain Volume Reduction in Multiple Sclerosis. J of IMAB. 2013 Jul-Dec;19(3):438-441. DOI: 10.5272/jimab.2013193.438.

Correspondence to: Ivan N. Dimitrov, MD, PhD, First Clinic of Neurology, “Sveta Marina“ University Hospital; 1 Hristo Smirnenski str., 9010 Varna, Bulgaria; e-mail:;

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Accepted for publication: 16 April 2013
Published online: 22 July 2013

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