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JIFACTOR:Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2014, vol. 20, issue 6
Subject Collection: Medicine
Pages: 556-559
DOI: 10.5272/jimab.2014206.556
Published online: 23 December 2014
J of IMAB 2014 Oct-Dec;20(6):556-559
BEVACIZUMAB COMBINED WITH IRINOTECAN, 5-FLUOROURACIL AND LEUCOVORIN AS THE FIRST- LINE TREATMENT IN PATIENTS WITH METASTATIC COLORECTAL CARCINOMA.
Deyan Davidov 
.
Department of Medical Oncology, Oncological Center - UMHAT "Dr Georgi Stranski", Medical University, Pleven, Bulgaria.
ABSTRACT:
Objective: Bevacizumab improved survival when added to chemotherapy for patients with metastatic colorectal cancer (mCRC). The aim of this study was to explore the efficacy and safety of Bevacizumab containing chemotherapy regimen in the treatment of patient with mCRC.
Methods: From January 2010 to March 2012 twenty two consecutive patients with inoperable mCRC entered the study. Treatment schedule consist of intravenous Irinotecan 180 mg/m2 on day 1, Leucovorin 200 mg/m2 administered as intravenous infusion on day 1 and 2 and 5- Fluorouracil 400 mg/m2 bolus and Bevacizumab 5 mg/kg as an intravenous infusion with repetition every two weeks.
Results: Overall response rate was 31,9% with one complete response and six partial responses achieved. The overall survival time was 16,6 months. The main toxicities observed were leukopenia and diarrhea.
Conclusions: That data suggest that chemotherapy with Irinotecan/ 5- Fluorouracil/ Leucovorin and Bevacizumab remain reasonable regimen for the treatment of patients with mCRC.
Key words: Bevacizumab, Chemotherapy, Metastatic colorectal cancer, Survival,
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Please cite this article in PubMed Style or AMA (American Medical Association) Style:
Davidov DN. Bevacizumab Combined with Irinotecan, 5-Fluorouracil and Leucovorin as the First- line Treatment in Patients with Metastatic Colorectal Carcinoma. J of IMAB. 2014 Oct-Dec;20(6):556-559. http://dx.doi.org/10.5272/jimab.2014206.556
Correspondence to: Dr Deyan Davidov, Department of Medical Oncology, Oncological Center, Medical University, Pleven; 1, "St. Kliment Ohridsky" Str., 5000 Pleven, Bulgaria; E-mail: dean_davidov@abv.bg
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Received: 28 September 2014
Published online: 23 December 2014