Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2015, vol. 21, issue 1
Subject Area: Medicine
Pages: 694-698
DOI: 10.5272/jimab.2015211.694
Published online: 10 February 2015

J of IMAB 2015 Jan-Mar;21(1):694-698
Adriana Ruseva1Corresponding Autor, Radka Lazarova1, Ilko Kosturkov1, Vesselina Ianachkova2, Stella Yordanova2, Zhivka Boneva2, Diana Nikolovska1.
1) Clinic of Gastroenterology, Medical Institute - Ministry of Interior, Sofia, Bulgaria
2) Department of Endocrinology, Medical Institute - Ministry of Interior, Sofia, Bulgaria

Colorectal cancer is one of the most common cancers worldwide. The role of the female sex hormones in the etiology of the disease is very intriguing. Reproductive factors are surrogate measure of lifetime exposition to the sex hormones.
Purpose: Our aim is to investigate the association between the reproductive factors and colorectal carcinoma risk.
Materials and methods: We include 234 Bulgarian women in our study – 117 cases with colorectal cancer and the same number of healthy controls. Cases are divided into three groups according to the localization of the tumor. We conduct case-control study, using questionnaires about reproductive factors. We use the following statistical methods – descriptive, variational analysis, binary logistic regression.
Results: We observed that only the age at menopause is associated with colorectal cancer risk, and this factor has strongest protective effect in the proximal colon (95% CI - 0,051-0,781, OR – 0,200, p – 0,021). Conclusion: Analyzing our data we observed that among Bulgarian women the only reproductive factor that show association with the risk of colorectal cancer is the age at menopause.

Key words: colorectal cancer, reproductive factors, risk factors, age at menopause,

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Please cite this article in PubMed Style or AMA (American Medical Association) Style:
Ruseva A, Lazarova R, Kosturkov I, Ianachkova V, Yordanova S, Boneva Z, Nikolovska D. Reproductive factors and colorectal cancer risk. Case - control study. J of IMAB. 2015 Jan-Mar;21(1):694-698. doi:

Correspondence to: Dr. Adriana H. Ruseva, Clinic of Gastroenterology, Medical Institute - Ministry of Interior, Sofia; 79, Skobelev blvd., Sofia, Bulgaria; E-mail:

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Received: 14 November 2014
Published online: 10 February 2015

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