 |
Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2015, vol. 21, issue 2
Subject Area: Medicine - Ophthalmology
Pages: 784-787
DOI: 10.5272/jimab.2015212.784
Published online: 11 June 2015
J of IMAB 2015 Apr-Jun;21(2):784-787
AMNIOTIC MEMBRANE TRANSPLANTATION FOR KERATITIS.
Snezhana Murgova1
, Chavdar Balabanov1, Mariela Oblashka2.
1) Eye Clinic, University Hospital, Medical University - Pleven, Bulgaria
2) Medical Center “Svetlina” - Pleven, Bulgaria.
ABSTRACT:
Keratitis without proper management tends to perforate the cornea, resulting in severe adverse consequences. In recent studies, amniotic membrane is reported to have anti-inflammatory effect and promote wound healing of corneal ulcer.
Purpose: To report on the efficacy of permanent amniotic membrane transplantation (AMT) in the treatment of keratitis.
Case report: A 58-year-old man with severe keratitis in both eyes caused by long term administration of topical anesthetic (alcaine) for electric ophthalmia. Single layer of amniotic membrane (AM) was placed on the defect and secured to the limbus with interrupted 10-0 nylon sutures. A bandage contact lens was applied on the AM. Postoperative medication included topical antibiotic, artificial tears and mydriatic. Three months later corticosteroid was included. There was an immediate decrease of patient’s pain after surgery. Complete epithelialization was noted after 1 month.
Conclusion: AMT is an alternative adjunctive method of treatment of keratitis; it promotes epithelialization process, decreased inflammation, corneal haze and neovascularization.
Key words: keratitis, corneal ulcer, amniotic membrane,
- Download FULL TEXT /PDF 6845 KB/
Please cite this article in PubMed Style or AMA (American Medical Association) Style:
Murgova S, Balabanov C, Oblashka M. AMNIOTIC MEMBRANE TRANSPLANTATION FOR KERATITIS. J of IMAB. 2015 Jan-Mar;21(2):784-787.
doi: http://dx.doi.org/10.5272/jimab.2015212.784
Correspondence to: D-r Snezhana Murgova, Eye clinic, UMBAL Dr George Stranski - II-nd Clinical Base; 91, Gen. Vladimir Vazov Str., 5800 Pleven, Bulgaria; E-mail: snejana_murgova@yahoo.com
REFERENCES:
1. Liu J, Sheha H, Fu Y, Liang L, Tseng SC. Update on amniotic membrane transplantation; Expert Rev Ophthalmol. 2010 Oct; 5(5): 645–661. [PubMed] [CrossRef]
2. Yildiz EH, Nurozler AB, Ozkan Aksoy N, Altiparmak UE, Onat M, Karaguzel H. Amniotic membrane transplantation: Indications and results. European Journal of Ophthalmology. 2008 Sep-Oct;18(5):685-690. [PubMed]
3. Dua HS, Azuara-Blanco A. Amniotic membrane transplantation. Br J Ophthalmol. 1999 Jun;83(6):748–752. [PubMed] [CrossRef]
4. Barequet I, Habot-Wilner Z, Keller N, Smollan G, Ziv H, Belkin M, et al. Effect of Amniotic Membrane Transplantation on the Healing of Bacterial Keratitis. Invest Ophthalmol VisSci. 2008 Jan;49(1):163–167. [PubMed] [CrossRef]
5. Dekaris I, Gabric N, Mravic I, Karaman Z, Katusic J, Lazic R, et al. Multilayer vs. Monolayer Amniotic Membrane Transplantation for Deep Corneal Ulcer Treatment. Coll Antropol. 2001; 25 Suppl:23–28. [PubMed]
6. Nejabat M, Masoumpour M, Eghtedari M, Azarpira N, Ashraf MJ, Astane AR. Amniotic Membrane Transplantation for theTreatment of Pseudomonas Keratitis in Experimental Rabbits. Iran Red Crescent Med J. 2009 Apr;11(2):149-154.
7. Heiligenhaus A, Li H, Galindo E, Koch J, Steuhl KP, Meller D. Management of acute ulcerative and necrotising herpes simplex and zoster keratitis with amniotic membrane transplantation. Br J Ophthalmol. 2003 Oct;87(10):1215–1219. [PubMed] [CrossRef]
8. Prabhasawat P, Tesavibul N, Komolsuradej W. Single and multilayer amniotic membrane transplantation for persistent corneal epithelial defect with and without stromal thinning and perforation. Br J Ophthalmol. 2001 Dec;85(12):1455–1463. [PubMed] [CrossRef]
9. Chen JH, Ma DH, Tsai RJ. Amniotic Membrane Transplantation for Pseudomonal Keratitis with Impending Perforation. Chang Gung Med J. 2002 Mar;25(30):144-52. [PubMed]
10. Solomon A, Meller D, Prabhasawat P, John T, Espana EM, Steuhl KP, et al. Amniotic Membrane Grafts for Nontraumatic Corneal Perforations,Descemetoceles, and Deep Ulcers. Ophthalmology. 2002 Apr;109(4):694–703. [PubMed] [CrossRef]
11. Sheha H, Liang L, Li J, Tseng SC. Sutureless Amniotic Membrane Transplantation for Severe Bacterial Keratitis. Cornea. 2009 Dec;28(10):1118–1123. [PubMed] [CrossRef]
12. Tseng S, Espana E, Kawakita T, Di Pascuale MA, Li W, He H, et al. How does amniotic membrane work? Ocul Surf. 2004 Jul;2(3)177-187. [PubMed]
13. Kim JS, Kim JC, Hahn TW, Park WC. Amniotic membrane transplantation in infectious corneal ulcer. Cornea. 2001 Oct;20(7):720–726. [PubMed]
14. Talmi YP, Sigler L, Inge E, Finkelstein Y, Zohar Y. Antibacterial properties of human amniotic membranes. Placenta. 1991 May-Jun;12(3):285-8. [PubMed] [CrossRef]
15. Resch M, Schlotzer-Schrehard U, Hofmann-Rummelt C, Sauer R, Cursiefen C, Kruse F, et al. Adhesion Structures of Amniotic Membranes Integrated into Human Corneas. Invest Ophthalmol Vis Sci. 2006 May;47(5):1853–1861. [PubMed] [CrossRef]
16. Resch M, Resch B, Csizmazia E, Imre L, Németh J, Szabó-Révész P, et al. Drug Reservoir Function of Human Amniotic Membrane. J Ocul Pharmacol Ther. 2011 Aug;27(4):323-6. [PubMed] [CrossRef].
Received: 14 February 2015
Published online: 11 June 2015