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Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2015, vol. 21, issue 2
Subject Area: Medicine - Infectious and Parasitic Diseases
Pages: 788-792
DOI: 10.5272/jimab.2015212.788
Published online: 11 June 2015
J of IMAB 2015 Apr-Jun;21(2):788-792
TUBERCULIN RESPONSE AND SCAR FORMATION IN BCG VACCINATED 7-YEARS OLD SCHOOLCHILDREN IN SOFIA, BULGARIA.
Tzvetelina Stefanova 
“BCG Vaccine” Laboratory, Bul Bio - National Center of Infectious and Parasitic Diseases Ltd., Sofia, Bulgaria.
ABSTRACT:
This study has been designed to evaluate safety and efficacy of BCG vaccine in school-entering children in terms of tuberculin response to PPD and scar formation as indicators for successful vaccination. 12 BCG lots were used to immunize 1054 tuberculin-negative children at age of 7 years. Local lesions were observed and recorded 1, 3 and 12 months after immunization, and tuberculin sensitivity was measured 3 months after BCG re-immunization. The mean diameter of local reaction was 5.58±1.63 mm at 1st month, 5.13±1.56 mm at 3rd month and 4.16±1.21 mm at 12th month respectively. Tuberculin conversion was 100% and the mean diameter of induration 3 months after BCG application was 10.53±1.66 mm. All of the results obtained pointed to the fact that Bulgarian BCG vaccine induces adequate tuberculin sensitivity to a low dose of PPD tuberculin without great local skin lesions and without occurrence of any untoward vaccination reactions. Very good consistency from batch to batch is observed and this is a proof that biological activity of the Bulgarian BCG strain is kept under continuous control.
Key words: BCG vaccine, Tuberculin sensitivity test, PPD, Delayed type of hypersensitivity,
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Please cite this article in PubMed Style or AMA (American Medical Association) Style:
Stefanova T. TUBERCULIN RESPONSE AND SCAR FORMATION IN BCG VACCINATED 7-YEARS OLD SCHOOLCHILDREN IN SOFIA, BULGARIA. J of IMAB. 2015 Jan-Mar;21(2):788-792.
doi: http://dx.doi.org/10.5272/jimab.2015212.788
Correspondence to: D-r Tzvetelina Stefanova, “BCG vaccine” Laboratory, Bul Bio – National Center of Infectious and Parasitic Diseases Ltd.; 26 Yanko Sakazov Blvd., 1504 Sofia, Bulgaria; E-mail: tzvetelina_dimkova@yahoo.com
REFERENCES:
1. Zwerling A, Behr MA, Verma A, Brewer TF, Menzies D, Pai M. The BCG World Atlas: A database of global BCG vaccination policies and practices. PLoS Med. 2011 Mar;8(3):e1001012. [PubMed] [CrossRef]
2. Briassoulis G, Karabatsou I, Gogoglou V, Tsorva A. BCG vaccination at three different age groups: response and effectiveness. J Immune Based Ther Vaccines. 2005 Apr 1;3(1):1. [PubMed] [CrossRef]
3. Roy A, Eisenhut M, Harris RJ, Rodrigues LC, Sridhar S, Habermann S et al. Effect of BCG vaccination against Mycobacterium tuberculosis infection in children: systematic review and meta-analysis. BMJ. 2014 Aug 5;349:g4643. [PubMed] [CrossRef]
4. Lönnroth K, Migliori GB, Abubakar I, D’Ambrosio L, de Vries G, Diel R. et al. Towards tuberculosis elimination: an action framework for low-incidence countries. Eur Respir J. 2015 Apr;45(4):928-52 [PubMed] [CrossRef]
5. WHO, Technical Report Series. 745, 1987
6. Sapundgieva E. Diagnostic possibilities of the purified tuberculins. Probl Inf Par Dis. 1991, vol. XVIII:112-116
7. Minchev PM. [Tuberculins and Tuberculin Sensitivity]. Act; 1996. 21 p. [in Bulgarian]
8. Ritz N, Dutta B, Donath S, Casalaz D, Connell TG, Tebruegge M et al. The influence of Bacille Calmette-Guérin vaccine strain on the immune response against tuberculosis: a randomized trial. Am J Respir Crit Care Med 2012 Jan 15;185(2):213–222. [PubMed] [CrossRef]
9. Weir RE, Gorak-Stolinska P, Floyd S, Lalor MK, Stenson S, Branson K, at al. Persistence of the immune response induced by BCG vaccination, BMC Infect Dis. 2008 Jan 25;8:9. [PubMed] [CrossRef]
10. Hoft D, Leonardi C, Milligan T, Nahass GT, Kemp B, Cook S, at al. Clinical reactogenicity of Intradermal Bacille Calmette-Guérin Vaccination. Clin Infec Dis. 1999 Apr;28(4):785-790. [PubMed] [CrossRef]
11. Hoft DF, Kemp EB, Marinaro M, Cruz O, Kiyono H, McGhee JR, et al. A double-blind, placebo-controlled study of Mycobacterium-specific human immune responses induced by intradermal bacille Calmette-Guerin vaccination. J Lab Clin Med. 1999 Sep;134(3):244-52. [PubMed] [CrossRef]
12. Ferreira AA, Ferreira Mde F, Macedo EA, Cunha I, Santos SL, Reis AR, et al. [BCG revaccination in school children: evolution of the lesion at the vaccination site between 48 hours and 10 weeks]. [in Portuguese] J Pediatr (Rio J). 2002 Jul-Aug;78(4):289-94. [PubMed].
Received: 12 March 2015
Published online: 11 June 2015