Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2015, vol. 21, issue 4
Subject Area: Medicine - Neurology
Pages: 914-921

Published online: 13 November 2015

J of IMAB 2015 Oct-Dec;21(4):914-921
Borislav D. Ivanov1Corresponding Autor, Ara G. Kaprelyan2, Pavel H. Bochev3, Ivan N. Dimitrov4, Margarita V. Grudkova2, Borislav G. Chaushev3, Anelia D. Klissarova3, Nadezhda S. Deleva2
1) Department of Clinical medical sciences, Medical University, Varna, Bulgaria.
2) Department of Neurological diseases and neurosciences, Medical University, Varna, Bulgaria.
3) Department of Imaging Diagnostics and radiotherapy, Medical University, Varna, Bulgaria.
4) Department of Healthcare, Sliven affiliate, Medical University, Varna, Bulgaria.

Introduction: A modest number of studies reported contradictory results for brain glucose metabolism in essential tremor (ET) patients.
Aim: To study the brain glucose metabolism in ET patients with (18F)-FDG PET/CT. 
Materials and Methods: Ten patients were included, aged 60.4 years, with 8 months diseases duration. Five healthy persons, aged 60.2 years, were studied as controls. Resting state (18F)-FDG PET/CT was performed according to a standard protocol on a Phillips Gemini TF scanner. Images acquired were evaluated visually and quantitatively with specialized software NeuroQ, v. 3.0 for Phillips EBW workstation. Differences from database mean of more than ±2.5 SD were considered significant in both cluster and region analysis.
Results: Significant hypometabolism in left temporal, parietal and frontal cortical areas, including Broca`s area and anterior cingulate cortex was found in 8 patients. One patient showed also significant hypermetabolism in cerebellar hemispheres, vermis, primary and associative visual cortical areas. Normal glucose metabolism was found in 2 patients and all the controls.
Conclusion: Our study confirmed the presence of functional abnormalities on (18F)-FDG PET/CT scans of ET patients in cortical and cerebellar areas and provides new data for possible changes in Broca`s area, visual areas, and anterior cingulate cortex.

Key words: Brain glucose metabolism, (18F)-FDG PET/CT, Essential tremor,

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Please cite this article in PubMed Style or AMA (American Medical Association) Style:
Ivanov BD, Kaprelyan AG, Bochev PH, Dimitrov IN, Grudkova MV, Chaushev BG, Klissarova AD, Deleva NS. (18F)-FDG PET/CT in Essential Tremor: Preliminary Results. J of IMAB. 2015 Oct-Dec;21(4):914-921.

Correspondence to: Borislav Ivanov, MD, PhD, Associate Professor of Neurology, Department of Clinical Medical Sciences, Dental Medicine Faculty, Medical University, Varna, Bulgaria; E-mail:

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Received: 16 July 2015
Published online: 13 November 2015

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