Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2015, vol. 21, issue 4
Subject Area: Medicine - Neurology
Pages: 948-952
DOI: 10.5272/jimab.2015214.948
Published online: 24 November 2015

J of IMAB 2015 Oct-Dec;21(4):948-952
Daniela ArabadzhievaCorresponding Autor, Ara G. Kaprelyan, Nevena Radeva
First Multiprofile Clinic of Neurology, Department of Neurology and Neurosciences, St. Marina University Hospital, Medical University of Varna, Bulgaria.

There is recent evidence of co-occurrence of benign and malignant brain tumours and cerebrovascular disorders in the same patients. The present concise review analyzes the newly-published foreign literature on this actual topic. The epidemiological investigations reveal an association between the acute ischaemic and haemorrhagic stroke, on the one hand, and some common cerebral neoplasms, on the other hand. The role of modern thrombolytic therapy in such patients is outlined. The risks of chemotherapy and radiotherapy for the development of stroke should be taken into consideration. A series of interesting rare cases illustrating the diagnostic and therapeutic opportunities in the patients presenting with simultaneous or consecutive common cerebral neoplasms and stroke proves the necessity of careful diagnosis and timely management of these patients in the routine clinical practice.

Key words: ischaemic stroke, haemorrhagic stroke, multiform glioblastoma, meningioma, epidemiology, diagnosis, treatment, case reports,

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Please cite this article in PubMed Style or AMA (American Medical Association) Style:
Arabadzhieva D, Kaprelyan AG, Radeva N. BRAIN NEOPLASMS IN PATIENTS WITH CEREBROVASCULAR DISEASES. J of IMAB. 2015 Oct-Dec;21(4):948-952.

Correspondence to: Daniela Arabadzhieva, MD, PhD; First Multiprofile Clinic of Neurology, Department of Neurology and Neurosciences, St. Marina University Hospital, Medical University of Varna; 1, Hristo Smirnenski Str.; 9010 Varna, Bulgaria; E-mail:

1. Guo YJ, Chang MH, Chen PL, Lee YS, Chang YC, Liao YC. Predictive value of plasma (D)-dimer levels for cancer-related stroke: a 3-year retrospective study. J Stroke Cerebrovasc Dis. 2014 Apr;23(4):e249-e254. [PubMed] [CrossRef]
2. Sanossian N, Djabiras C, Mack WJ, Ovbiagele B. Trends in cancer diagnoses among inpatients hospitalized with stroke. J Stroke Cerebrovasc Dis. 2013 Oct;22(7):1146-1150. [PubMed] [CrossRef]
3. Kim JM, Jung KH, Park KH, Lee ST, Chu K, Roh JK. Clinical manifestation of cancer related stroke: retrospective case-control study. J Neurooncol. 2013 Feb;111(3):295-301. [PubMed] [CrossRef]
4. Kreisl TN, Toothaker T, Karimi S, DeAngelis LM. Ischemic stroke in patients with primary brain tumors. Neurology. 2008 Jun 10;70(24):2314-2320. [PubMed] [CrossRef]
5. Zöller B, Ji J, Sundquist J, Sundquist K. Risk of haemorrhagic and ischaemic stroke in patients with cancer: a nationwide follow-up study from Sweden. Eur J Cancer. 2012 Aug;48(12):1875-1883. [PubMed]
6. Li XL, Zhou FM, Shangguan SQ, Zou WQ, Deng YQ, Chen T, et al. Application of computed tomography for differential diagnosis of glioma stroke and simple cerebral hemorrhage. Asian Pac J Cancer Prev. 2014;15(8):3425-3428. [PubMed] [CrossRef]
7. Noje C, Cohen K, Jordan LC. Hemorrhagic and ischemic stroke in children with cancer. Pediatr Neurol. 2013 Oct;49(4):237-242. [PubMed] [CrossRef]
8. Murthy SB, Moradiya Y, Shah S, Shastri A, Bershad EM, Suarez JI. In-hospital outcomes of thrombolysis for acute ischemic stroke in patients with primary brain tumors. J Clin Neurosci. 2015 Mar;22(3):474-478. [PubMed] [CrossRef]
9. Etgen T, Steinich I, Gsottschneider L. Thrombolysis for ischemic stroke in patients with brain tumors. J Stroke Cerebrovasc Dis. 2014 Feb;23(2):361-366. [PubMed] [CrossRef]
10. Abt NB, Bydon M, De la Garza-Ramos R, McGovern K, Olivi A, Huang J, et al. Concurrent neoadjuvant chemotherapy is an independent risk factor of stroke,all-cause morbidity, and mortality in patients undergoing brain tumor resection. J Clin Neurosci. 2014 Nov;21(11):1895-1900. [PubMed] [CrossRef]
11. Fraum TJ, Kreisl TN, Sul J, Fine HA, Iwamoto FM. Ischemic stroke and intracranial hemorrhage in glioma patients on antiangiogenic therapy. J Neurooncol. 2011 Nov;105(2):281-289. [PubMed] [CrossRef]
12. Campen CJ, Kranick SM, Kasner SE, Kessler SK, Zimmerman RA, Lustig R, et al. Cranial irradiation increases risk of stroke in pediatric brain tumor survivors. Stroke. 2012 Nov;43(11):3035-3040. [PubMed] [CrossRef]
13. Brown PD, Blanchard M, Jethwa K, Flemming KD, Brown CA, Kline RW, et al. The incidence of cerebrovascular accidents and second brain tumors in patients with pituitary adenoma: a population-based study. Neurooncol Pract. 2014 Mar;1(1):22-28. [PubMed] [CrossRef]
14. Neil W, Ovbiagele B. Intravenous thrombolysis in ischemic stroke patients with intracranial neoplasms: two cases and a literature review. Case Rep Med. 2011;2011:503758. [PubMed] [CrossRef].
15. Dafer RM, Paleologos N, Lynch D. Intravenous thrombolysis for ischemic stroke in recurrent oligodendroglioma: a case report. J Stroke Cerebrovasc Dis. 2014 May-Jun;23(5):1235-1238. [PubMed] [CrossRef]
16. Baiense RF, Abrahão A, Ricarte IF, Fukuda TG, Oliveira RA, Silva GS, et al. Successful intra-arterial thrombolysis in a patient with an intracranial meningioma. J Stroke Cerebrovasc Dis. 2013 Nov;22(8):e658-e660. [PubMed] [CrossRef]
17. Missori P, Morselli C, Fattapposta F, Peschillo S, Currà A. Ischaemic stroke with partial haemorrhagic transformation related to a small-sized tuberculum sellae meningioma. Neurol Sci. 2015 Apr;36(4):649-651. [PubMed] [CrossRef]
18. Masuoka J, Yoshioka F, Ohgushi H, Kawashima M, Matsushima T. Meningioma manifesting as cerebral infarction. Neurol Med Chir (Tokyo). 2010; 50(7):585-587. [PubMed] [CrossRef]
19. Mathis S, Bataille B, Boucebci S, Jeantet M, Ciron J, Vandamme L, et al. A rare cause of stroke in young adults: occlusion of the middle cerebral artery by a meningioma postpartum. Case Rep Neurol Med. 2013;2013:652538. [PubMed] [CrossRef]
20. Chow HK, Yousafzai SM, Ugurlucan  M, Canver CC. Silent meningioma - a rare cause of stroke in post-cardiopulmonary bypasspatients. Arch Med Sci. 2010 Apr 30;6(2):176-180. [PubMed] [CrossRef]
21. Pina S, Carneiro Â, Rodrigues T, Samões R, Taipa R, Melo-Pires M, et al. Acute ischemic stroke secondary to glioblastoma. A case report. Neuroradiol J. 2014 Feb;27(1):85-90. [PubMed] [CrossRef]
22. Chen H, Cebula H, Schott R, Dietemann JL, Froelich S. Glioblastoma multiforme presenting with ischemic stroke: case report and review of the literature. J Neuroradiol. 2011 Dec;38(5):304-307. [PubMed] [CrossRef]
23. Ojemakinde O, Gonzalez Toledo E, Wilson J. A case of glioblastoma in infarcted brain. J La State Med Soc. 2013 Jan-Feb;165(1):30-32. [PubMed]
24. Vermani N, Mann HS, Brar RS, Bagai M. Cerebellar glioblastoma presenting with clinical and imaging features of posterior circulation stroke. J Postgrad Med. 2010 Apr-Jun;56(2):152-153. [PubMed] [CrossRef]
25. Wojtasiewicz TJ, Ducruet AF, Noticewala SS, Canoll P, McKhann GM 2nd. De novo glioblastoma in the territory of a prior middle cerebral artery infarct. Case Rep Neurol Med. 2013; 2013:356526. [PubMed] [CrossRef].
26. Li L, Yin J, Li Y, Tian W, Qiao B, Tang Z, et al. Anaplastic astrocytoma masquerading as hemorrhagic stroke. J Clin Neurosci. 2013 Nov;20(11):1612-1614. [PubMed] [CrossRef].

Received: 15 July 2015
Published online: 24 November 2015

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