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Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2020, vol. 26, issue4
Subject Area: Medicine
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DOI: 10.5272/jimab.2020264.3449
Published online: 19 November 2020
Original article
J of IMAB. 2020 Oct-Dec;26(4):3449-3451
SERUM LEVELS OF ADENOSINE DEAMINASE IN PATIENTS WITH TUBERCULOSIS AND INFLAMMATORY LUNG DISEASE
Irena I. Gencheva
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Department of Clinical Laboratory, Clinical Immunology and Allergology, Medical University – Pleven, Bulgaria.
ABSTRACT:
Introduction: Serum adenosine deaminase (ADA) levels are used to diagnose tuberculosis and to monitor the condition of the patients during hospital treatment.
Purpose: The aim of the present study is to establish the diagnostic value of serum ADA in patients with inflammatory lung disease, including pulmonary tuberculosis.
Materials and methods: We measured ADA levels in 66 patients with lung disease, of whom 33 were men and 33 were women, all aged 18 to 86 years. Among the patients studied, 12 were diagnosed with tuberculosis, 34 with bacterial pneumonia and 20 with pleural effusion.
Results: We found that the serum ADA levels in our patients were higher than 18 U / l, which are the recommended upper limit in healthy people, according to the test performed by our laboratory. ADA levels were also higher than 21 U / l, the value we defined as the mean in healthy individuals in our previous study.
Conclusion: Based on our study, we can say that serum ADA levels in the patients we have studied with lung diseases, including pulmonary tuberculosis, have a high diagnostic value.
Keywords: ADA, diagnosis, tuberculosis,
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Please cite this article as: Gencheva II. Serum levels of adenosine deaminase in patients with tuberculosis and inflammatory lung disease. J of IMAB. 2020 Oct-Dec;26(4):3449-3451. DOI: 10.5272/jimab.2020264.3449
Correspondence to: Irena I. Gencheva, Department of Clinical laboratory, Clinical Immunology and Allergology, Medical University – Pleven, Bulgaria; E-mail: gencheva1677@gmail.com
REFERENCES:
1. Alaarag AH, Mohammad OI, Faraq NM.Diagnostic utility of serum adenosine deaminase level in the diagnosis of pulmonary tuberculosis. Egypt J Bronchol. 2016; 10(2):133-9. [Crossref]
2. Navari K, Eftekhaari TE, Ziaee N, Navari F. Decreasing level of serum ADA: A valuable predictor of treatment in smear positive tuberculosis. European Respiratory Journal. 2011; 38(Suppl 55):p4382.
3. Boloursaz M, Khalilzadeh S, Khodayari A, Hakimi S. Adenosine Deaminase Level as an Indicator for Differentiating Between Active Pulmonary Tuberculosis Infection and Other Pulmonary Infections. ComprPed. 2012; 3(1):3-6. [Crossref]
4. Farazi A, Moharamkhani A, Sofian M. Validity of serum adenosine deaminase in diagnosis of tuberculosis. Pan Afr Med J. 2013 Aug 14;15:133. [PubMed] [Crossref]
5. Jhamaria JP, Jenaw RK, Luh SK, Mathur DK, Parihar HL, Sharma SK.Serum adenosine deaminase (ADA) in differential diagnosis of pulmonary tuberculosis and common non tubercular respiratory diseases. Ind J Tub. 1988; 35:25-27.
6. Varma S, Toppo A. Estimation of Serum Adenosine Deaminase Levelin Patients of Pulmonary Tuberculosisin a Tertiary Care Hospital in Chhattisgarh. Int J Res Health Sci.2015 Oct-Dec;3(4):451-456. [Internet ]
7. Afrasiabian S, Mohsenpour B, Bagheri KH, Sigari N,& Aftabi K. Diagnostic value of serum adenosine deaminase level in pulmonary tuberculosis. J Res Med Sci. 2013 Mar;18(3):252-4. [PubMed]
8. Farahmand F, Tajdini P, Falahi G, Shams S, Mahmoudi S. Evaluation of Serum Adenosine Deaminase in Cystic Fibrosis Patients in an Iranian Referral Hospital. Iran J Pediatr. 2016 Feb 10;26(3):e2246. [PubMed] [Crossref]
9. Gencheva II, Angelova IA, Ruseva AL. Serum Adenosine Deaminase Values In Healthy People. J B Bio Engine. 2020 Jun; 1(1):2. [Crossref]
10. Conde MB, Marinho SR, de Fatima Pereira M, Lapa e Silva JR, Saad MHF, Sales CL, et al. The usefulness of serum adenosine deaminase 2 (ADA2) activity in adults for the diagnosis of pulmonary tuberculosis. Respir Med. 2002 Aug;96(8):607-10. [PubMed] [Crossref]
11. Gupta BK, Bharat V, Bandyopadhyay D. Sensitivity, specificity, negative and positive predictive values of adenosine deaminase in patients of tubercular and non-tubercular serosal effusion in India. J Clin Med Res. 2010 May 19;2(3):121-6.[PubMed] [Crossref]
12. Aggarwal AN, Agarwal R, Sehgal IS, Dhooria S. Adenosine deaminase for diagnosis of tuberculous pleural effusion: A systematic review and meta-analysis. PLoS One. 2019 Mar 26;14(3):e0213728. [PubMed] [Crossref]. ].
Received: 19 October 2019
Published online: 19 November 2020