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Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2020, vol. 26, issue4
Subject Area: Medicine
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DOI: 10.5272/jimab.2020264.3469
Published online: 24 November 2020
Review article
J of IMAB. 2020 Oct-Dec;26(4):3469-3474
THE NON-MOTOR SYMPTOMS–CHALLENGE IN DIAGNOSIS OF PARKINSON'S DISEASE
Desislava Marinova
, Maya Danovska,
Department Neurology and Neurosurgery, Faculty Medicine, Medical University, Pleven, Bulgaria.
ABSTRACT:
Parkinson's disease (PD) is the second most common neurodegenerative disorder after the dementia of Alzheimer. The clinical presentation of PD is dominated by typical motor symptoms as resting tremor, cogwheel rigidity, bradykinesia, and postural instability. Non-motor symptoms (NMS) of Parkinson's disease are common but are often under-recognized in clinical practice either due to the lack of spontaneous complaints by the patients or to the absence of systematic questioning by healthcare professionals. In contrast to motor dysfunctions, non-motor symptoms frequently remain unreported. Recently, a self-completed NMS questionnaire and NMS scale for identification and evaluation of these symptoms have been validated. An international survey has shown that up to 62% of NMS in PD remain undeclared to healthcare professionals because patients are unaware that NMS symptoms are linked to PD. Based on both clinical and neuropathological data, PD, traditionally accepted as a dopaminergic motor disorder, now can be characterized as a multisystem neurodegenerative disease that involves many neurotransmitter systems and affects not only motor but non-motor functions, too.
Keywords: Parkinson's disease (PD), Non-motor symptoms (NMS), quality of life,
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Please cite this article as: Marinova D, Danovska M. The non-motor symptoms–challenge in diagnosis of Parkinson's Disease. J of IMAB. 2020 Oct-Dec;26(4):3469-3474. DOI: 10.5272/jimab.2020264.3469
Correspondence to: Dr Desislava Marinova, Department of Neurology and Neurosurgery, Neurology Clinic, Medical University - Pleven; 1, St Kliment Ohridski str., 5800 Pleven, Bulgaria; E-mail: desislavamar@gmail.com
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Received: 28 October 2019
Published online: 24 November 2020