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Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2008, vol. 14, book 1
Subject Collection: Medicine
Page: 3-5
DOI: 10.5272/jimab.14-1-2010.3
Online date: May 22, 2008
J of IMAB 2008; 14(1):3-5
FLOWCYTOMETRY IN LEPTOSPIROSIS
Galya I. Gancheva1
, Maria Atanasova1, Tzvetan Lukanov2, Penka Ilieva1
1) Department of Infectious Diseases, Epidemiology, Parasitology, and Tropical Medicine, Medical University, Pleven, Bulgaria
2) Sector of Clinical Immunology, Medical University, Pleven, Bulgaria
ABSTRACT:
Differential count of leucocytes and six lymphocyte populations and subpopulations were investigated by flow cytometry in fourteen cases with leptospirosis. Marked granulocytosis and lymphopenia were found in 100%. The percentage of the monocytes was significantly decreased (mean 6,65%; 0,7 to 14,0%; sd 5,49). Immunophenotypization of lymphocyte populations and subpopulations by flow cytometry was revealed prevalent tendencies for decreasing of the number of total T-lymphocytes, T-helpers, T-suppressors, T-helpers/T-suppressors index; increasing of the number of the activated T-lymphocytes, subpopulation of NK cells (CD3-/ CD16+56+), and B-lymphocyte. These data are suggested that cell-mediated immunity plays a role in later stages of the diseases.
Key words: leptospirosis, immunogenesis, flow cytometry, lymphocyte subpopulations, dysregulation,
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Please cite this article as:
Gancheva GI, Atanasova M, Lukanov Tz., Ilieva P. FLOWCYTOMETRY IN LEPTOSPIROSIS. J of IMAB 2008; 14(1):3-5. DOI: 10.5272/jimab.14-1-2010.3
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