back to 2008, vol. 14, b. 1

Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2008, vol. 14, book 1
Subject Collection: Medicine
Page: 72-75
DOI: 10.5272/jimab.14-1-2010.72
Online date: October 07, 2008

J of IMAB 2008; 14(1)72-75
Valentin Valtchev1, Virginia Simeonova2, Dimitar Gospodinov1, Ivelina Yordanova1,Valentina Dimitrova1, Verka Pavlova1, E. Konova4, Savelina Popovska3, Boyko Stamenov2
1) Department of Dermatology and Venereology, 2) Department of Neurology, 3) Department of General and Clinical Pathology, 4) Department of Immunology, Medical University – Pleven, Bulgaria

Sneddon’s syndrome is usually characterized by the association of an ischemic cerebrovascular disease and a widespread livedo reticularis. The incidence of Sneddon syndrome is 4/1000 000. We present 42-year-old woman with livedo reticularis, recurrence ischaemic cerebrovascular accidents, two repetitive miscarriages and positive anti-2GPi antibodies. Skin biopsy specimens reveal inflammatory changes of small- to medium-sized arteries and subendothelial proliferation and fibrosis. The diagnosis Sneddon syndrome is confirmed by skin biopsy, and MR evidence.
We suggest that anti-2GPi antibodies may be pathophysiologically related to the clinical manifestation observed in some patients with Sneddon syndrome.

Key words: Sneddon syndrome, livedo reticularis, ischemic cerebrovascular disease.

- Download FULL TEXT (PDF - 372 KB)
Please cite this article as: Valtchev V, Simeonova V, Gospodinov D, Yordanova I, Dimitrova V, Pavlova V, Konova E, Popovska S, Stamenov B. SNEDDON’S SYNDROME. J of IMAB 2008; 14(1):72-75. DOI: 10.5272/jimab.14-1-2010.72

1. Baleva M, Chauchev A, Dikova C et al. Sneddon syndrome: echocardiographic, neurological and immunological findings. Stroke 1995;26(7):1303-4.
2. Blom RJ. Sneddon syndrome: CT, arteriography and MR imaging. J Comput Assist Tomogr 1989;13(1):119-22.
3. Fine RM. Sneddon syndrome: a diagnosis you do not want to miss. Int J Dermatol 1990;29(7):479-80.
4. Gancheva M., Tsankov N.  Livedo reticularis and cerebrovascular accident (Sneddon’s Syndrome) as a clinical expression of antiphospholipid syndrome. J EUR Acad Dermatol Venereol 1999; 12(2): 157-160.
5. Geschwind DH, FitzPatrick M, Mischel PS, Cummings JL. Sneddon's syndrome is a thrombotic vasculopathy: neuropathologic and neuroradiologic evidence. Neurology 1995;45(3 Pt 1):557-60.
6. Levine SR, Langer SL, Alberts JW, Welch KMA. Sneddon's syndrome: an antiphospholipid antibody syndrome? Neurology 1988;38(5):798-800.
7. Marsch WC, Muckelmann R. Generalized racemosa livedo with cerebrovascular lesions (Sneddon syndrome): an occlusive arteriolopathy due to proliferation and migration of medial smooth muscle cells. Br J Dermatol 1995;112(6):703-8.
8. Richard MA, Grob JJ, Durand JM, Noe C, Basseres N, Bonerandi JJ. Le syndrome de Sneddon. Ann Dermatol Venereol 1994;121(4):331-7.
9. Sempere AP, Martinez B, Bermejo F, Tahoces MF, Cabello A. Sneddon's syndrome: its clinical characteristics and etiopathogenic factors. Rev Clin Esp 1992;191(1):3-7.
10. Sneddon IB. Cerebro-vascular lesions and livedo reticularis. Br J Dermatol 1965;77:180-5.
11. Zelger B, Sepp N, Schmid KW, Hintner H, Klein G, Fritsch PO. Life history of cutaneous vascular lesions in Sneddon's syndrome. Hum Pathol 1992;23(6):668-75.
12. Zelger B, Sepp N, Stockhammer G et al. Sneddon's syndrome. A long term follow-up of 21 patients. Arch Dermatol. 1993;129(4):437-47.

back to Online Journal