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Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2011, vol. 17, book 1
Subject Collection: Medicine
Page: 127-129
DOI: 10.5272/jimab.2011171.127
Online date: May, 2011
J of IMAB 2011; 17(1):127-129
SYNTHESIS OF OLIGOPEPTIDES OF DEFINED FRAGMENT COMPOSITION
Tamara Paypanova1, Tatyana Hristova2, Rumyana Cherkezova2
1) Institute of Molecular Biology, Bulgarian Academy of Sciences - Sofia, Bulgaria;
2) Department of Medical and Biological Sciences, Faculty of Dental Medicine, Medical University - Varna, Bulgaria
ABSTRACT:
The advantages of the solid-phase peptide synthesis were used. The peptide chain was built on specially processed insoluble polymer resin: Wang- and Rink Amide MBHA-resin. Three new fragment oligopeptides were prepared by activation and condensation of Fmoc-protected amino acids [which were subject of our previous work]. One of the important advantages of Fmoc-strategy is achieved: no continuous unblocking of the protection group is effected and the formed peptide bonds do not break.
Key words: solid-phase peptide synthesis, oligopeptide fragments.
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Please cite this article as: Paypanova T, Hristova T, Cherkezova R. SYNTHESIS OF OLIGOPEPTIDES OF DEFINED FRAGMENT COMPOSITION. J of IMAB 2011; 17(1):127-129. doi: 10.5272/jimab.2011171.127