back to 2011, vol. 17, b. 1

Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2011, vol. 17, book 1
Subject Collection: Medicine
Page: 152-153
DOI: 10.5272/jimab.2011171.152
Online date: October 7, 2011

J of IMAB 2011; 17(1):152-153
Zahariy Krastev1, Ivan Stoev2, Deian Jelev1, Aneta Ivanova1, Krasimir Antonov1, Luydmila Mateva1
1) Clinic of Gastroenterology, St. Ivan Rilsky University Hospital, Sofia, Bulgaria; 2) General Practitioner in village of Ablaniza, Bulgaria

Objective: HBV-infection is intermediate-endemic in Bulgaria. There is a trend for decreasing of HBsAg-carrier rate in the last decades, but prevalence remains higher in some specific ethnic communities. Current data regarding high-endemic sources of HBV-infection are limited.
Methods: HBsAg and anti-HCV were tested in 677 subjects from a specific ethnical community: 413 adults and 264 adolescents, covered by the National Program for HBV-vaccination of all newborns.
Results: Thirty-two of adults (7,7%) were HBsAg-positive. The observed HBsAg-carrier rate was more than three folds higher than general Bulgarian population. In contrast only 2/264 (0.7%) of adolescents were HBsAg-positive. They both were born from HBsAg-positive mothers. Anti-HCV-positive subjects have been found neither among adults nor among adolescents.     
Conclusion: Our results confirmed existence of separate high-endemic sources of HBV infection in Bulgaria. HBV vaccination program is highly effective even in such specific subgroups and resulted in marked decrease of HBsAg-carrier rate among adolescents.

Key words: HBV epidemiology, HBsAg prevalence, ethnical groups, HBV vaccination .

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1. Gubev E, Rashkov R, Dimitrova T, Sharankov N, Andonov A. [Comparative studies of the distribution of hepatitis B markers among blood donors and patients with post-transfusion hepatitis in the city of Sofia]. Vutr. Bolesti 1987; 26(3): 38 - 43. (in Bulgarian) [PubMed]
2. Kojuharova M, Kourtchatova A, team. Surveillance, epidemiology and prevention of Hepatitis B in Bulgaria: results of the feasibility survey.
3. Krastev Z, Jelev D. Hepatitis B virus infection in Bulgaria. VIII National Congress of Infectious Diseases, 16-18 October 2008, Sofia, Abstract Book: 19 – 22. (in Bulgarian)
4. Gatcheva N, Vladimirova N, Kourtchatova A. Implementing universal vaccination programs: Bulgaria. Vaccine 1995; 13 (Suppl 1): S82 – S83. [PubMed]
5. Ivanova A, Krasteva A, Panov V, Jelev D, Antonov K, Krastev Z. Is saliva dangerouse in transmission in HBV hepatitis? Gut 2008; 57 (Suppl. II): A288. (Abstract)
6. Alter MJ. Epidemiology of hepatitis B in Europe and worldwide. J Hepatol. 2003, 39 Supl 1:S64–9. [PubMed]
7. EASL.  Clinical Practice Guidelines: management of chronic hepatitis B. J Hepatol., 2009 Feb;50(2): 227-42. doi: 10.1016/j.jhep.2008.10.001 CrossRef] [PubMed]
8. Lok AS, McMahon BJ. Chronic Hepatitis B: AASLD Practice Guidelines. Hepatology, 2007 Feb;45(2): 507-539. doi: 10.1002/hep.21513 CrossRef] [PubMed]

Please cite this article as: Krastev Z, Stoev I, Jelev D, Ivanova A, Antonov K, Mateva L. High prevalence of HBsAg carriers in a specific community in Bulgaria. J of IMAB 2011; 17(1):152-153. doi: 10.5272/jimab.2011171.152

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