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Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2011, vol. 17, book 1
Subject Collection: Medicine
Page: 154-157
DOI: 10.5272/jimab.2011171.154
Online date: October 7, 2011
J of IMAB 2011; 17(1):154-157
PREDICTORS OF SUSTAINED RESPONSE TO INTERFERON-BASED THERAPY IN CHRONIC HEPATITIS B
Deian Jelev, Krasimir Antonov, Aneta Ivanova, Zahariy Krastev
Clinic of Gastroenterology, St. Ivan Rilsky University Hospital, Sofia, Bulgaria
ABSTRACT:
Objective: IFN-based therapy induces long-term remission in ~20% of CHB-patients. Identification of predictors of treatment response can facilitate the clinical decision.
Methods: 168 CHB-patients treated with IFN-based therapy were studied. Predictors of end-of-treatment response (ETR) and sustained response (SR) one-year post therapy were identified by non-parametric chi-square test and correlation analysis.
Results: Low baseline HBV DNA (<50,000,000 cp/ml) and high ALT level (>4xULN) were independent predictors of ETR. Low viral load was stronger predictor than high ALT level. If both factors coexist the probability of ETR was 92%. In HBeAg-negative subjects SR correlates significantly with age below 40 years, evidence of early viral response at 3rd month, fibrosis stage F<3 (METAVIR) and prolongation of treatment duration. HBeAg-seroconversion up to 6-month post-therapy was the strongest predictor of SR in HBeAg-positive patients.
Conclusion: More favorable results could be achieved by pretreatment selection according to patients’ age, baseline viral load, ALT and liver fibrosis. Extension of IFN-treatment in responders may enhance the SR rate.
Key words: HBV, IFN, Peg IFN, predictors, treatment.
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Please cite this article as: Jelev D, Antonov Kr, Ivanova A, Krastev Z. Predictors of sustained response to interferon-based therapy in chronic hepatitis B. J of IMAB 2011; 17(1):154-157. doi: 10.5272/jimab.2011171.154