back to 2011, vol. 17, b. 1

Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2011, vol. 17, book 1
Subject Collection: Medicine
Page: 183-188
DOI: 10.5272/jimab.2011171.183
Online date: December 29, 2011

J of IMAB 2011; 17(1):183-188
Mirena Valkova, Boyko Stamenov, Dora Peychinska, Maya Danovska
Department of Neurology and Neurosurgery, Medical University - Pleven, Bulgaria

Introduction: The objective of our study was to examine cognitive status, short – term memory, delayed recall and the retention of visual information in diabetics with polyneuropathy and to establish the impacts of some risk factors on cognitive performance.
Contingent and methods: We assessed 47 diabetic patients with polyneuropathy, using the Mini Mental State Examination, 10 words test, the Benton visual retention test and the Hamilton scale.
Results: Global cognitive dysfunction, decline in verbal memory and visual retention and tendency for depressive mood were observed. We found statistically significant interaction of ageing, sex, severity of pain, duration and late onset of diabetes mellitus (DM) on cognitive functioning. Therapy association on cognition was not found.
Conclusions: Our study confirms the hypothesis of global cognitive dysfunction, associated with diabetic polyneuropathy. The interactions of sex and pain severity require further study. We arise a hypothesis of asymmetrical brain injury in diabetics.

Key words: diabetic polyneuropathy, global cognitive functioning, retention of visual information, verbal memory.

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Please cite this article as: Valkova M, Stamenov B, Peychinska D, Danovska M. Cognitive dysfunctions in diabetic polyneuropathy. J of IMAB. 2011; 17(1):183-188. doi:10.5272/jimab.2011171.183

1. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2004 Jan;27 Suppl 1:S5-S10. [CrossRef] [PubMed]
2. Hassenstab JJ, Sweat V, Bruehl H, Convit A. Metabolic syndrome is associated with learning and recall impairment in middle age. Dement Geriatr Cogn Disord. 2010;29(4):356-62. [CrossRef] [PubMed]
3. Messier C. Impact of impaired glucose tolerance and type 2 diabetes on cognitive aging. Neurobiol Aging. 2005 Dec;26 Suppl 1:26-30. [CrossRef] [PubMed]
4. Cukierman-Yaffe T, Gerstein HC, Williamson JD, Lazar RM, Lovato L, Miller ME, et al. Relationship between baseline glycemic control and cognitive function in individuals with type 2 diabetes and other cardiovascular risk factors: the action to control cardiovascular risk in diabetes-memory in diabetes (ACCORD-MIND) trial. Diabetes Care. 2009 Feb;32(2):221-6. [PubMed] [CrossRef]
5. Raffaitin C, Féart C, Le Goff M, Amieva H, Helmer C, Akbaraly TN, et al.. Metabolic syndrome and cognitive decline in French elders: the Three-City Study. Neurology. 2011 Feb 8;76(6):518-25. Epub 2011 Feb 2. [PubMed]
6. Bruce DG, Casey GP, Grange V, Clarnette RC, Almeida OP, Foster JK, et al. Cognitive impairment, physical disability and depressive symptoms in older diabetic patients: the Fremantle Cognition in Diabetes Study. Diabetes Res Clin Pract. 2003 Jul;61(1):59–67. [PubMed] [CrossRef]
7. Munshi M, Grande L, Hayes M, Ayres D, Suhl E, Capelson R, et al. Cognitive dysfunction is associated with poor diabetes control in older adults. Diabetes Care 2006 Aug;29(8):1794–1799. [PubMed] [CrossRef]
8. Kouta Y, Sakurai T, Yokono K.  Cognitive dysfunction and dementia associated with elderly diabetes. Nippon Rinsho. 2006 Jan;64(1):119-23. (Article in Japanese) [PubMed]
9. Robertson-Tchabo EA, Arenberg D, Tobin JD, Plotz JB. A longitudinal study of cognitive performance in noninsulin dependent (type II) diabetic men. Exp Gerontol. 1986;21(4-5):459-67. [CrossRef] [PubMed]
10. Reaven GM, Thompson LW, Nahum D, Haskins E. Relationship between hyperglycemia and cognitive function in older NIDDM patients. Diabetes Care 1990 Jan;13(1):16–21. [Pubmed]
11. Skenazy JA, Bigler ED. Neuropsychological findings in diabetes mellitus. J Clin Psychol 1984 Jan;40(1):246–258. [PubMed]
12. Fontbonne A, Berr C, Ducimetiere P, Alperovitch A. Changes in cognitive abilities over a 4-year period are unfavorably affected in elderly diabetic subjects: results of the Epidemiology of Vascular Aging Study. Diabetes Care 2001 Feb;24(2):366–370. [CrossRef] [PubMed]
13. Luchsinger JA, Tang MX, Stern Y, Shea S, Mayeux R. Diabetes mellitus and risk of Alzheimer’s disease and dementia with stroke in a multiethnic cohort. Am J Epidemiol 2001, 154:635–641. doi: 10.1093/aje/154.7.635 CrossRef] [PubMed]
14. de Bresser J, Reijmer YD, van den Berg E, Breedijk MA, Kappelle LJ, Viergever MA, et al. Microvascular determinants of cognitive decline and brain volume change in elderly patients with type 2 diabetes. Dement Geriatr Cogn Disord. 2010;30(5):381-6. [CrossRef] [PubMed]
15. Grodstein F, Chen J, Wilson RS, Manson JE Type 2 diabetes and cognitive function in community-dwelling elderly women. Diabetes Care 2001, 24:1060–1065. [CrossRef] [PubMed]
16. Roberts RO, Geda YE, Knopman DS, Christianson TJ, Pankratz VS, Boeve BF, et al.. Association of duration and severity of diabetes mellitus with mild cognitive impairment. Arch Neurol. 2008 Aug;65(8):1066-73. [PubMed]
17. Ding J, Strachan MW, Reynolds RM, Frier BM, Deary IJ, Fowkes FG, et al. Diabetic retinopathy and cognitive decline in older people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study. Diabetes. 2010 Nov;59(11):2883-9. [CrossRef] [PubMed].

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