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Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2013, vol. 19, book 3;
Subject Collection: Medicine
Page: 442-447
DOI: 10.5272/jimab.2013193.442
Published online: 04 August 2013
J of IMAB. 2013 Jul-Dec;19(3):442-447;
THE CYTOKINE IP-10 IN CHRONIC HBV AND HCV INFECTION
Nina S. Nikolova 
, Krasimir Antonov, Deian Jelev, Lyudmila Mateva, Zahariy Krastev.
Clinic of Gastroenterology, University Hospital "St. Ivan Rilski" - Sofia,
Medical University - Sofia, Bulgaria.
ABSTRACT:
Introduction: IP-10 it has been studied as a predictor of treatment response in chronic HCV infected patients. The data for the HBV infection are not enough.
Aim: To compare IP-10 levels in patients with chronic HBV /CHB/ and HCV infection /CHC/ and their relation to liver disease and treatment response.
Material and methods: 20 patients - with CHC genotype 1 infection /on standard bi-therapy/ and 32 patients with CHB /21 pts - NUC; 11 pts - IFN/.
Results: The IP-10 did not correlate with sex, age, ALT and liver fibrosis. The basal IP-10 were lower in patients with CHB (p=0,017). There was a difference in IP-10 baseline levels among the HCV patients with or without RVR (p=0,007). A negative correlation was found between basal IP-10 and RVR (r= -0,508; p=0,008).
Conclusion: IP-10 could predict virological response in patients with CHC on standard bi-therapy, but not in HBV infected patients on standard therapy.
Key words: IP-10, chronic HCV, HBV infection, response.
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Please cite this article as:
Nikolova NS, Antonov K, Jelev D, Mateva L, Krastev Z. THE CYTOKINE IP-10 IN CHRONIC HBV AND HCV INFECTION. J of IMAB. 2013 Jul-Dec;19(3):442-447. DOI: 10.5272/jimab.2013193.442.
Correspondence to: Nina S. Nikolova, MD, Sector "General Medicine", University Hospital "St Ivan Rilski" – Clinic of Gastroenterology - Sofia, Medical University - Sofia, Bulgaria; 15, Acad. Ivan Geshov, bld., 1431 Sofia, Bulgaria; ns.nikolova@yahoo.com
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Accepted for publication: 24 April 2013
Published online: 04 August 2013