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Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2013, vol. 19, book 4
Subject Collection: Oral and Dental Medicine
Pages: 392-395
DOI: 10.5272/jimab.2013194.392
Published online: 15 October 2013
J of IMAB 2013; 19(4):392-395
RARE CASE OF MULTIFOCAL EPITHELIAL HYPERPLASIA OF ORAL MUCOSA.
Elitsa G. Deliverska 1
, Maria Dencheva2.
1) Department of Oral and Maxillofacial surgery,
2) Department of Oral Imaging and Oral Diagnostic,
Faculty of Dental Medicine, Medical University Sofia, Bulgaria.
ABSTRACT:
Introduction: Multifocal papilloma virus epithelial hyperplasia (MPVEH) is a rare disease of the oral mucosa associated with the human papilloma viruses (HPV) 13 and 32. It occurs at any age, but children have the highest incidence.
Purpose: To present a case of oral multifocal papilloma virus epithelial hyperplasia with palatal tumour and multiple metachronic primary cancers.
Material and methods: The medical history shows a 60 years female patient with complaints of asymptomatic mass on the palatal mucosa, with a two years’ development. The patient has been treated surgically for previous thyroid cancer, endometrial cancer and cancer of the mammary gland. An incisional biopsy has been performed in her left buccal mucosa 10 years ago and histopathological examination confirmed the diagnosis of MPVEH.
The palatal tumour was removed surgically by electroexcision and the histological result was pleomorphic adenoma of a small palatal salivary gland.
Conclusion: Papillomatosis is considered as a benign neoplasm with an unpredictable course and with a low probability of malignancy.We report of an unusual case of MPVEH persistent for more than 30 years without regression and with significant impact on a patient‘s quality of life.
Key words: Multifocal papilloma virus epithelial hyperplasia; palatal tumour; multiple primary tumours;
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Please cite this article as:
Deliverska EG, Dencheva M. Rare case of multifocal epithelial hyperplasia of oral mucosa. J of IMAB. 2013; 19(4):392-395. doi: 10.5272/jimab.2013194.392.
Correspondence to: dr Elitsa Deliverska, Department of Oral and Maxillofacial surgery, Faculty of Dental Medicine,
1, Georgi Sofiyski blvd., 1431 Sofia, Bulgaria; e-mail: elitsadeliverska@yahoo.com
REFERENCES:
1. Archard HO, Heck JW, Stanley HR. Focal epithelial hyperplasia: an unusual oral mucosal lesion found in Indian children. Oral Surg Oral Med Oral Pathol. 1965 Aug;20:201-12. [PubMed]
2. Bombeccari GP, Pallotti F, Guzzi G, Spadari F. Diode laser therapy for Heck’s disease associated with HPV13 infection. J Eur Acad Dermatol Venereol. 2009 Feb;23(2):197-8. [PubMed] [CrossRef]
3. Blyumin M, Khachemoune A. What is your diagnosis? Focal epithelial hyperplasia (Heck disease). Cutis. 2006 Apr;77(4):217, 233-4. [PubMed]
4. Cohen PR, Hebert AA, Adler-Storthz K. Focal epithelial hyperplasia: Heck disease. Pediatr Dermatol. 1993 Sep;10(3):245-51. [PubMed]
5. Garcia-Corona C, Vega-Memije E, Mosqueda-Taylor A, Yamamoto-Furusho JK, Rodriguez-Carreon AA, Ruiz-Morales JA, et al. Association of HLA-DR4 (DRBI*0404) with human papilloma virus infection in patients with focal epithelia hyperplasia. Arch Dermatol. 2004 Oct;140(10):1227-31. [PubMed] [CrossRef]
6. Greenspan D, de Villers EM. Greenspan JS, deSouza YG, zur Hausen H. Unusual HPV types in oral warts in association with HIV infection. J Oral Pathol. 1998 Nov;17(9-10):482-8. [PubMed]
7. Hall C, McCullough M, Angel C, Manton D. Multifocal epithelial hyperplasia: a case report of a family of Somalian descent living in Australia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Jan;109(1):e20-24. [PubMed] [CrossRef]
8. Hettwer KJ, Rodgers MS. Focal epithelial hyperplasia (Heck’s disease) in a Polynesian. Oral Surg Oral Med Oral Pathol. 1966 Oct;22(4):466-70. [PubMed]
9. Ledesma-Montes C, Garces-Ortiz M, Hernandez-Guerrero JC. Clinicopathological and immunocytochemical study of multifocal epithelial hyperplasia. J Oral Maxillofac Surg. 2007 Nov;65(11): 2211-7. [PubMed] [CrossRef]
10. March CJ. Multiple papillary tumours of the labial, buccal and glossal mucous membrane. Dental Cosmos 1881;23:165.
11. Parkin DM, Almonte M, Bruni L, Clifford G, Curado MP, Piñeros M. Burden and Trends of Type-Specific Human Papillomavirus Infections and Related Diseases in the Latin America and Caribbean Region, Vaccine. 2008 Aug 19;26 Suppl 11:L1-15. [PubMed] [CrossRef]
12. Requena L, Requena C. [Histopathology of the more common viral skin infections]. [in Spanish] Actas Dermosifiliogr. 2010 Apr;101(3):201-16. [PubMed] [CrossRef]
13. Segura-Saint-Gerons R, Toro-Rojas M, Ceballos-Salobreña A, Aparicio-Soria JL, Fuentes-Vaamonde H. Focal epithelial hyperplasia. A rare disease in our area. Med Oral Patol Oral Cir Bucal. 2005 Mar-Apr;10(2):128-31. [PubMed]
14. Vera-Iglesias E, Garcia-Arpa M, Sanchez-Caminero P, Romero- Aguilera G, Cortina de la Calle P. Focal epithelial hyperplasia. Actas Dermosifiliogr. 2007 Nov;98(9):621-3. [PubMed] [CrossRef]
15. Witkop CJ Jr, Niswander JD. Focal epithelial hyperplasia in Central and South American Indians and Ladinos. Oral Surg Oral Med Oral Pathol. 1965 Aug;20:213-7. [PubMed].
Received: 20 July 2013
Published online: 15 October 2013