 |
Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2014, vol. 20, issue 3
Subject Collection: Oral and Dental Medicine
Pages: 563-566
DOI: 10.5272/jimab.2014203.563
Published online: 19 August 2014
J of IMAB 2014 Jul-Sep;20(3):563-566
CORRELATION OF GENE EXPRESSION OF MAIN INFLAMMATORY CITOKINS AND THE SEVERITY OF CHRONIC PERIODONTITIS.
Christina Popova
, Velitchka Dosseva-Panova, Antoaneta Mlachkova.
Department of Periodontology, Faculty of Dental Medicine, Medical University, Sofia, Bulgaria.
ABSTRACT:
The understanding of the pathogenesis of periodontitis makes various progresses in the last decades. Today it is well known that the synthesis of high levels of pro-inflammatory mediators from gingival tissues in response to periodontal pathogens results in destruction of soft and hard periodontal tissues and clinical expression of periodontal disease. The occurrence of increased IL-6, IL-1β, TNFα and PGE2 levels in GCF or gingival tissue is capable to indicate risk of progression of destruction in specific periodontal site. Detection of gene expression of numerous major cytokines in high levels in gingival tissues and crevicular fluid may be indicator for activity of periodontitis and provides the rationale for the additional periodontal therapy. The current conception of the pathogenesis of periodontitis suggests that additional host modulation approach may inhibit the production of pro-inflammatory mediators in periodontal tissues and thus may enhance the treatment result.
Key words: chronic periodontitis, gene expression, IL-6, IL-1β, TNF-α, PGE2,
- Download FULL TEXT /PDF 811 KB/
Please cite this article in PubMed Style or AMA (American Medical Association) Style:
Popova Chr, Dosseva-Panova V, Mlachkova A. CORRELATION OF GENE EXPRESSION OF MAIN INFLAMMATORY CITOKINS AND THE SEVERITY OF CHRONIC PERIODONTITIS. J of IMAB. 2014 Jul-Sep;20(3):563-566. doi: http://dx.doi.org/10.5272/jimab.2014203.563.
Correspondence to: Prof. Christina Popova, Department of Periodontology, Faculty of Dental Medicine, Medical University - Sofia; 1, St. George Sofiiski Str., 1431 Sofia, Bulgaria; E-mail: hrpopova@yahoo.com
REFERENCES:
1. Bartold P, Van Dike T. Periodontitis: a host-mediated disruption of microbial homeostasis. Unlearning learned concepts. Periodontol 2000. 2013 62(1):203–217. [PubMed] [CrossRef]
2. Ebersole J, Dawson D, Morford L, Peyyala R, Miller C, Gonzales O. Periodontal disease immunology: ‘double indemnity’ in protecting the host. Periodontol 2000. 2013 Jun;62(1):163–202 [PubMed] [CrossRef]
3. Kinane D, Attstrom R. Advances in the pathogenesis of periodontitis: group B consensus report of the fifth European Workshop in Periodontology. J Clin Periodontol 2005; 32(Suppl 6):130-131. [PubMed]
4. Kornman K. Host modulation as a therapeutic strategy in the treatment of periodontal disease. Clin Infect Dis. 1999 Mar;28(3):520-526. [PubMed] [CrossRef]
5. Masada M, Persson R, Kenney J, Lee S, Page R, Allison A. Measurement of interleukin -1 alfa and interleukin -1 beta in gingival crevicular fluid: implications for the pathogenesis of periodontal disease. J Periodontal Res. 1990 May;25(3):156-163. [PubMed]
6. Taylor JJ. Cytokine regulation of immune responses to Porphyromonas gingivalis. Periodontol 2000. 2010 Oct;54(1):160-194. [PubMed] [CrossRef]
7. Tipton DA, Flynn JC, Stein SH, Dabbous MKh. Cyclooxygenase – 2 inhibitors decrea- se interleukin -1 beta - stimulatet prostaglandin E2 and IL-6 production by human gingival fibroblasts. J Periodontol. 2003 Dec;74(12):1754-1763. [PubMed] [CrossRef]
8. Vardar S, Baylas H, Huseyinov A. Effect of selective cyclo- oxygenase-2 inhibition on ginival tissue levels of prostaglandin E2 and prostaglandin F2α and clinical parameters of chronic periodontitis. J Periodontol. 2003 Jan;74(1):57-63. [PubMed] [CrossRef]
9. Popova Chr, Mlachkova A, Kicheva M. Tag Man RT-PCR method for evaluation of IL-1β and PGE2 levels in the gingival tissue in patients with chronic periodontitis. Problems of dental medicine. 2009; XXXV(2):8-15. [in Bulgarian]
10. Delima AJ, Oates T, Assuma R, Schwartz Z, Cochran D, Amar S, et al. Soluble antagonists to interleukin-1(IL-1) and tumor necrosis factor (TNF) inhibits loss of tissue attachment in experimental periodontitis. J Clin Periodontol. 2001 Mar;28(3):233-240. [PubMed]
11. Ejeil AL, Gaultier F, Igondjo-Tchen S, Senni K, Pellat B, Godeau G, et al. Are cytokines linked to collagen breakdoun during periodontal disease progression? J Periodontol. 2003 Feb;74(2):196-201. [PubMed] [CrossRef]
12. Geivelis M, Turner DW, Pederson ED, Lamberts BL. Measurements of interleukin-6 in gingival crevicular fluid from adults with destructive periodontal disease. J Periodontol. 1993 Oct;64(10);980-983. [PubMed] [CrossRef]
13. Raunio T, Nixdorf M, Knuuttila M, Karttunen R, Vainio O, Tervonen T. The extent of periodontal disease and the IL-6_174 genotype as determinants of serum IL-6 level. J Clin Periodontol. 2007 Dec;34(12):1025–1030. [PubMed] [CrossRef]
14. Dinarello CA. The many worlds of reducing interleukin-1. Arthritis Reum. 2005 Jul;52(7):1960-1967. [PubMed] [CrossRef]
15. Giulietti A, Overbergh L, Valckx D, Bouillon R, Decallonne B, Mathieu Ch. An overview of real- time quantitative PCR: Applications to quantify cytokine gene expression. Methods. 2001 Dec;25(4):386-401. [PubMed] [CrossRef]
16. Roberts FA, McCaffery KA, Michalek SM. Profile of cytokine mRNA expression in chronic adult periodontitis. J Dent Res. 1997 Dec;76(12):1833-9. [PubMed] [CrossRef]
17. Salvi GE, Lang NP. Host response modulation in the management of periodontal diseases. J Clin Periodontol. 2005 Oct;32(Suppl. 6):108-129. [PubMed] [CrossRef]
18. Van Dyke T. Control of inflammation and periodontitis. Periodontol 2000. 2007 Oct;45(1):158-166. [PubMed] [CrossRef]
19. Taylor J. Cytokine regulation of immune responses to Porphyromonas gingivalis. Periodontol 2000. 2010 Oct;54(1):160–194. [PubMed] [CrossRef]
20. Kirkwood KL, Taba M Jr, Rossa C Jr, Preshaw PM, Giannobile WV. Molecular biology of the host-microbe interaction in periodontal diseases: selected topics: molecular signaling aspects of pathogen-mediated bone destruction in periodontal diseases. In Carranza’s Clinical Periodontology / [edited by] Newman MG, Takei HH, Klokkevold PR, Carranza FF. 10th ed., W.B Saunders Company, Philadelphia, 2006; Chapter 15.
Received: 17 June 2014
Published online: 19 August 2014