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Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2015, vol. 21, issue 3
Subject Area: Medicine - Pharmacology
Pages: 818-822
DOI: 10.5272/jimab.2015213.818
Published online: 27 July 2015
J of IMAB 2015 Jul-Sep;21(3):818-822
NEW PHARMACOLOGICAL APPROACHES IN THE TREATMENT OF ONCOLOGICAL DISEASES.
Kaloyan D. Georgiev
, Marieta Georgieva.
Sector Pharmacology and Toxicology, Department of Preclinical and Clinical Sciences, Faculty of Pharmacy, Medical University Varna, Bulgaria.
ABSTRACT:
Malignant diseases are significant and growing health problem in almost all countries of the world. Besides the results achieved in reduction of morbidity and mortality in individual countries, significant progress of science and practice of oncology medicine and the application of new methods of diagnosis and treatment, cancer remains the second leading cause of death after cardiovascular diseases. The past decade has seen breakthroughs in personalized cancer medicine, where new targeted therapies are being developed which inhibit cellular proliferation and survival in tumors with certain specific oncogenic mutations. These new treatment approaches have shown progress in the understanding of the origin and pathogenesis of tumors, and offer hope for a good outcome of neoplastic diseases. In this review the idea is to present up-to-date report on these new molecular mechanisms and to identify their advantages and disadvantages from the pharmacological point of view.
Key words: antineoplastic drugs, oncology diseases, tyrosine-kinase inhibitors, cyclin-dependent kinases, monoclonal antibodies,
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Please cite this article in PubMed Style or AMA (American Medical Association) Style:
Georgiev KD, Georgieva M. New pharmacological approaches in the treatment of oncological diseases. J of IMAB. 2015 Jul-Sep;21(3):818-822. doi: http://dx.doi.org/10.5272/jimab.2015213.818
Correspondence to: Kaloyan D. Georgiev, Department of Preclinical and Clinical Sciences, Sector Pharmacology and Toxicology, Medical University, 55, Marin Drinov str., 9002 Varna, Bulgaria; E-mail: kalgeorgiev@hotmail.com
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Received: 04 April 2015
Published online: 27 July 2015