Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2015, vol. 21, issue 3
Subject Area: Medicine
Pages: 856-858
DOI: 10.5272/jimab.2015213.856
Published online: 08 September 2015

J of IMAB 2015 Jul-Sep;21(3):856-858
NONTUBERCULOUS TUBERCULOSIS CAUSED BY MYCOBACTERIUM GORDONAE - CLINICAL CASE REPORT
Gabriela Tsankova1Corresponding Autor, Violina Kaludova1, Tatina Todorova1, Neli Ermenlieva1, Emilia Georgieva2
1) Department of Preclinical and Clinical Sciences, Faculty of Pharmacy, Medical University Varna
2) Medical College Varna, Medical University Varna, Bulgaria.

ABSTRACT:
Background: Mycobacterium gordonae is a slow growing mycobacterium usually found in soil, tap water, and as laboratory contaminant. It is occasionally implicated in different infections in immunosuppressed patients. In contrast, there have been few case reports of active infection in immunocompetent individuals.
Case Description: We report a case of a 46-old immunocompetent patient with long-term cough and poor expectoration. A computed tomography of the chest revealed punctiform lesions and fibrosis formation in the upper right lobe. It did not show any infiltrate in lung parenchyma. Mycobacterium gordonae was definitively diagnosed by genetic method. After antituberculosis treatment the toxic infectious syndrome was overcome.
Conclusion: Mycobacterium gordonae is reported to cause clinically significant nontuberculosis infection in both immunocompetent and immunosuppressed individuals.
Mycobacterium gordonae is hardly diagnosed with traditional laboratory methods, but the latest molecular techniques allow successful isolation and identification of slow growing Mycobacterium gordonae.

Key words: Lung diseases Mycobacterium gordonae, Nontuberculous mycobacteria,

- Download FULL TEXT /PDF 489 KB/
Please cite this article in PubMed Style or AMA (American Medical Association) Style:
Tsankova G, Kaludova V, Todorova T, Ermenlieva N, Georgieva E. Nontuberculous tuberculosis caused by Mycobacterium gordonae - clinical case report. J of IMAB. 2015 Jul-Sep;21(3):856-858. doi: http://dx.doi.org/10.5272/jimab.2015213.856

Correspondence to: Gabriela Tsankova, Department of preclinical and clinical sciences, Faculty of Pharmacy, Medical University of Varna; 55, Marin Drinov Str., 9002 Varna, Bulgaria; E-mail: gabriela_sc@abv.bg

REFERENCES:
1. Nei T, Okabe M, Mikami I, Koizumi Y, Mase H, Matsuda K, et al. A non-HIV case with disseminated Mycobacterium kansasii disease associated with strong neutralizing autoantibody to interferon-г. Respir Med Case Reports. 2013; 8:10-3. [PubMed] [CrossRef]
2.  Cassidy PM, Hedberg K, Saulson A, McNelly E, Winthrop KL. Nontuberculous mycobacterial disease prevalence and risk factors: a changing epidemiology. Clin Infect Dis. 2009 Dec;49(12):e124-9. [PubMed] [CrossRef]
3. Molicotti P, Bua A, Cannas S, Cubeddu M, Ruggeri M, Pirina P, et al. Identification of non-tuberculous mycobacteria from clinical samples. New Microbiol. 2013 Oct;36(4):409–11. [PubMed]
4.  Saleeb P, Olivier KN. Pulmonary nontuberculous mycobacterial disease: new insights into risk factors for susceptibility, epidemiology, and approaches to management in immunocompetent and immunocompromised patients. Curr Infect Dis Rep. 2010 May;12(3):198–203. [PubMed] [CrossRef]
5.  Brener ZZ, Zhuravenko I, Bergman M. Acute kidney injury in a patient with nontuberculous mycobacterial infections: a case report. Cases J. 2009 Jan;2(1):83. [PubMed] [CrossRef]
6.  Kim HS, Lee Y, Lee S, Kim YA, Sun YK. Recent trends in clinically significant nontuberculous mycobacteria isolates at a korean general hospital. Ann Lab Med. 2014 Jan;34(1):56-9. [PubMed] [CrossRef]
7.  Arend SM, van Soolingen D, Ottenhoff THM. Diagnosis and treatment of lung infection with nontuberculous mycobacteria. Curr Opin Pulm Med. 2009 May;15(3):201-8. [CrossRef]
8.  Douglas JG, Calder MA, Choo-kang YFJ, Leitch AG. Short reports. Mycobacterium gordonae: a new pathogen?. Thorax. 1986; 41:152-3.
9.  García García JM, Palacios Gutiérrez JJ, Sánchez Antuña AA. Respiratory Infections Caused by Environmental Mycobacteria. Arch Bronconeumol (English Ed.). 2005 Apr;41(4):206-19. [PubMed] [CrossRef]
10. Arnow PM, Bakir M, Thompson K, Bova JL. Endemic contamination of clinical specimens by Mycobacterium gordonae. Clin Infect Dis. 2000 Aug;31(2):472–6. [PubMed]
11.  Foti C, Sforza V, Rizzo C, De Pascale G, Bonamonte D, Conserva A, et al. Cutaneous manifestations of Mycobacterium gordonae infection described for the first time in Italy: a case report. Cases J. 2009 Jul;2(1):6828. [PubMed]
12. Youssef D, Shams WE, Elshenawy Y, El-Abbassi A, Moorman JP. Pulmonary infection with caseating mediastinal lymphadenitis caused by Mycobacterium gordonae. Int J Mycobacteriology. 2014 Sep;3(3):220–3. [CrossRef]
13. Barber TW, Craven DE, Farber HW. Mycobacterium gordonae: a possible opportunistic respiratory tract pathogen in patients with advanced human immunodeficiency virus, type 1 infection. Chest. 1991 Sep;100(3):716-20. [PubMed] [CrossRef]
14. Afessa B. Mycobacterial and nonbacterial pulmonary complications in hospitalized patients with human immunodeficiency virus infection: A prospective, cohort study. BMC Pulm Med. 2001; 1(1):1. [PubMed] [CrossRef]
15. Pinho L, Santos J, Oliveira G, Pestana M. Mycobacterium gordonae urinary infection in a renal transplant recipient. Transpl Infect Dis. 2009 Jun;11(3):253–6. [PubMed] [CrossRef]
16. Murata T, Ishikawa E, Ito T, Matsuo H, Nakamura A, Mitarai S, et al. Repeated acute kidney injury associated with Mycobacterium gordonae infection. CEN Case Rep. 2014; [CrossRef]
17. Rudra P, Rajesh S, Pritam N. Pulmonary Infection with Mycobacterium Gordonae in an Immunocompetent Patient: A Case Report. A JIDM. 2014; 2(1):1-3. [CrossRef]
18. Mazumder SA, Hicks A, Norwood J. Mycobacterium gordonae pulmonary infection in an immunocompetent adult. N Am J Med Sci. 2010 Apr;2(4):205–7. [PubMed].

Received: 07 June 2015
Published online: 08 September 2015

back to Online Journal