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Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2015, vol. 21, issue 3
Subject Area: Medicine
Pages: 887-890
DOI: 10.5272/jimab.2015213.887
Published online: 29 September 2015
J of IMAB 2015 Jul-Sep;21(3):887-890
PREVALENCE OF VITAMIN D DEFICIENCY IN DIFFERENT GROUPS OF CHRONIC RENAL FAILURE PATIENTS.
Bistra T. Galunska1
, Daniela I. Gerova2, Dobrin N. Paskalev3, Rositza Y. Zorcheva3, Valentin Ch. Ikonomov3, Valentin Vladimirov4, Dobrin A. Svinarov5,
1) Department of Pharmaceutical Technology, Faculty of Pharmacy, Medical University of Varna, Bulgaria
2) Department of General Medicine and Clinical Laboratory, Faculty of Public Health, Medical University of Varna, Bulgaria
3) Department of Nephrology, Acute and Peritoneal Dialysis, Apheresis and Transplantation, University Hospital “St. Marina”, Medical University of Varna, Bulgaria
4) Department of Urology, University Hospital "Tsaritsa Yoanna", Medical University of Sofia, Bulgaria
5) Central Laboratory of TDM and Clinical Pharmacology, Faculty of Medicine, Medical University of Sofia, Bulgaria.
ABSTRACT:
Purpose: To determine and compare the vitamin D status of different groups CKD patients on hemodialysis, peritoneal dialysis, or no renal replacement therapy and to evaluate the effect of vitamin D therapy.
Patients and Methods: This pilot study enrolled 40 consecutive CKD patients (21 men, 19 women) divided into three groups: 15 CKD patients in 1,2,3,4 stage of the disease without renal replacement therapy (RRT); 10CKD patients on hemodialysis (HD) and 15 CKD patients on peritoneal dialysis (PD), ten of which were on vitamin D therapy. Vitamin D status was determined by serum 25-xydroxyvitamin D (25OHD).
Results: Ninety percent of patients were in vitamin D deficiency/insufficiency; and only 4 patients (10.0%) reached 25OHD levels above 75nmol/L. The median 25OHD level was 31.15nmol/L (interquartile range: 16.67-48.33nmol/L).Tendency of worse vitamin D status in women than in men was observed. Higher 25OHD levels were found in pre-dialysis patients (median 44.81nmol/L, 25%-75% percentile 16.24-52.21nmol/L) and lower in HD (median 31.15nmol/L, 25%-75% percentile 13.04-64.45nmol/L) and PD patients (median 33.38nmol/L, 25%-75% percentile 23.15-48.49nmol/L), but the difference did not reach statistical significance. Better vitamin D status was found in the PD group of patients receiving vitamin D preparations (p<0.05).
Conclusions: 25OHD deficiency/insufficiency is prevalent in renal failure patients with or without renal replacement therapy. It seems that vitamin D therapy improves the vitamin D status of PD patients. Further larger studies are needed to clarify the effect of specific type vitamin D therapy on serum 25OHD levels and clinical outcome in different groups of CKD patients.
Key words: chronic kidney disease, hemodialysis, peritoneal dialysis, vitamin D status, 25-hydroxyvitamin D,
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Please cite this article in PubMed Style or AMA (American Medical Association) Style:
Galunska BT, Gerova DI, PaskalevDN, Zorcheva BY, Ikonomov VC, Vladimirov V, Svinarov DA. PREVALENCE OF VITAMIN D DEFICIENCY IN DIFFERENT GROUPS OF CHRONIC RENAL FAILURE PATIENTS. J of IMAB. 2015 Jul-Sep;21(3):887-890. doi: http://dx.doi.org/10.5272/jimab.2015213.887
Correspondence to: Bistra Galunska, Department of Pharmaceutical Sciences, Medical University of Varna; 55, Marin Drinov Str., 9002 Varna, Bulgaria; E-mail: bistra.galunska@gmail.com
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Received: 03 August 2015
Published online: 29 September 2015