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Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2016, vol. 22, issue 1
Subject Area: Medicine
Pages: 1036-1038
DOI: 10.5272/jimab.2016221.1036
Published online: 09 March 2016
J of IMAB 2016 Jan-Mar;22(1):1036-1038
OUR EXPERIENCE WITH DACARBAZINE IN THE TREATMENT OF PATIENTS WITH INOPERABLE SKIN MELANOMA
Deyan Davidov
.
Department of Medical Oncology, UMHAT- Dr. G. Stranski, Medical University, Pleven, Bulgaria.
ABSTRACT:
Objective: The standard treatment for inoperable skin melanoma is chemotherapy. The aim of this study was to explore the efficacy and safety of therapy with dacarbazine in patients with advanced melanoma.
Methods: Twenty- seven consecutive patients with inoperable stage III or IV skin melanoma were treated with chemotherapy. Treatment schedule consists of dacarbazine 150 mg/ m2 days 1- 5 administered every 3- 4 weeks.
Results: Overall response rate was 14,8% with four partial remissions. The main toxicity were neutropenia and vomitus.
Conclusions: These data confirm that advanced skin melanoma is resistant of chemotherapy with dacarbazine.
Key words: Chemotherapy, Skin melanoma, Survival,
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Please cite this article in PubMed Style or AMA (American Medical Association) Style:
Davidov D. Our Experience with Dacarbazine in the Treatment of Patients with Inoperable Skin Melanoma. J of IMAB. 2016 Jan-Mar;22(1):1036-1038. DOI: http://dx.doi.org/10.5272/jimab.2016221.1036.
Correspondence to: Dr Deyan Davidov, Department of Medical Oncology, Medical University, Pleven; 1, "St. Kliment Ohridsky" Str., 5000 Pleven, Bulgaria; E-mail: dean_davidov@abv.bg
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Received: 30 November 2015
Published online: 09 March 2016