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Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2016, vol. 22, issue 2
Subject Area: Medicine
Pages: 1132-1135
DOI: 10.5272/jimab.2016222.1132
Published online: 31 May 2016
J of IMAB 2016 Apr-Jun;22(2):1132-1135
PEDIATRIC URINARY INFECTIONS, CAUSED BY EXTENDED-SPECTRUM BETA-LACTAMASE - PRODUCING MICROORGANISMS IN VARNA, BULGARIA
Neli M. Ermenlieva1 
, Dimitrichka D. Bliznakova2, Gabriela S. Tsankova1, Tsvetelina K. Popova2, Emiliq P. Georgieva2, Tatina T. Todorova2.
1) Department of Preclinical and Clinical Sciences, Faculty of Pharmacy, Medical University - Varna, Bulgaria.
2) Medical College, Medical University - Varna, Bulgaria.
ABSTRACT:
Background: Extended-spectrum beta-lactamase (ESBLs) producing bacteria are microorganisms which have the ability to hydrolyze β-lactame ring of a large part of the antibiotics, commonly used to treat bacterial infections including urinary tract infections.
Purpose: The aim of this study is present the epidemiology of childhood urinary tract infections caused by ESBL-producing strains in Varna, Bulgaria.
Material/methods: A total of 3895 urine samples of children patients (aged 0 to 18 years) were examined during the period 2010-2012 for presence of ESBL-producing bacteria.
Results: Six percent of the tested urinary samples were positive for ESBL production. All of the isolates were resistant to ampicillin, piperacillin, cephalothin, cefprozil, cefuroxime, ceftriaxone, ceftazidime, levofloxacin, cefaclor, but were were sensitive to meropenem and imipenem.
Conclusions: Cephalosporins and penicillins are the most used antibiotics in Bulgaria, but they should be very precisely prescribed in medical practice, because otherwise preconditions for maintaining high share of ESBLs are created.
Key words: Extended-spectrum beta-lactamase producing bacteria, urinary tract infections, pediatric infections, antibiotic resistance,
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Please cite this article in PubMed Style or AMA (American Medical Association) Style:
Ermenlieva NM, Bliznakova DD, Tsankova GS, Popova TK, Georgieva EP, Todorova TT. PEDIATRIC URINARY INFECTIONS, CAUSED BY EXTENDED-SPECTRUM BETA-LACTAMASE - PRODUCING MICROORGANISMS IN VARNA, BULGARIA. J of IMAB. 2016 Apr-Jun;22(2):1132-1135. DOI: http://dx.doi.org/10.5272/jimab.2016222.1132.
Correspondence to: Neli Mitkova Ermenlieva, Department of Preclinical and Clinical Sciences, Faculty of Pharmacy, Medical University-Varna; 55, Marin Drinov Str., 9002 Varna, Bulgaria; E-mail: Neli.Ermenlieva@mu-varna.bg
REFERENCES:
1. Akram M, Shahid M, Khan A. Etiology and antibiotic resistance patterns of community-acquired urinary tract infections in J N M C Hospital Aligarh, India. Ann Clin Microbiol Antimicrob. 2007 Mar;6:4. [PubMed] [CrossRef]
2. Woodford N. Sundsfjord A. Molecular detection of antibiotic resistance: when and where. J Antimicrob Chemother. 2005 Aug;56(2):259–261. [PubMed] [CrossRef]
3. Hamze M, Mallat H, Rachkidi J, Achkar M. The prevalence of Extended spectrum β-lactamases (ESBLs) producing Enterobacteriaceae isolated from urinary tract infection in children from northern Lebanon. Poster of Session: Antibiotic resistance. 30th Annual Meeting of the ESPID, Thessaloniki, Greece. 2012,
4. Stamm W, Norrby S. Urinary tract infections: disease panorama and challenges. J Infect Dis. 2001 Mar;183(Suppl 1):S1-4. [PubMed] [CrossRef]
5. Dobreva N. [Urinary tract infections.] [in Bulgarian] MedInfo.bg. 2015 Aug;8:68-73.
6. Bradford P. Extended-spectrum β-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. Clin Microbiol Rev. 2001 Oct;14(4):933-951. [PubMed] [CrossRef]
7. Lodozova N. Extended-spectrum beta-lactamase-producing microorganisms as causes of urinary tract infections in ambulatory and hospitalized patients in childhood - characteristics and epidemiology. [Dissertation] [in Bulgarian] Medical University of Varna; 2015; p.76-77.
8. Rodríguez-Baño J, Navarro M, Romero L, Martínez-Martínez L, Muniain M, Perea E, et al. Epidemiology and Clinical Features of Infections Caused by Extended-Spectrum Beta-Lactamase-Producing Escherichia coli in Nonhospitalized Patients. J Clin Microbiol. 2004 Mar;42(3):1089-1094. [PubMed] [CrossRef]
9. Daoud Z, Moubareck C, Hokime N Doucet-Populaire F. Extended spectrum β-lactamase producing Enterobacteriaceae in Lebanese ICU patients: Epidemiology and patterns of resistance. J Gen Appl Microbiol. 2006 Jun;52(3):169-178. [PubMed] [CrossRef]
10. Mugnaioli C, Luzzaro F, De Luca F, Brigante G, Perilli M, Amicosante G, et al. CTX-M-Type Extended-spectrum β-lactamases in Italy: Molecular epidemiology of an emerging countrywide problem. Antimicrob Agents Chemother. 2006 Aug;50(8):2700-2706. [PubMed] [CrossRef]
11. Aktas Z, Kayacan C, Schneider I, Can B, Midilli K, Bauernfeind A. Carbapenem hydrolyzing oxacillinase, OXA-48, persists in Klebsiella pneumoniae in Istanbul, Turkey. Chemotherapy. 2008 Feb;54(2):101–106. [PubMed] [CrossRef]
12. Luzzaro F, Gesu G, Endimiani A, Ortisi G, Malandrin S, Pagani L, et al. Performance in detection and reporting β-lactam resistance phenotypes in Enterobacteriaceae: a nationwide proficiency study in Italian laboratories. Diagn Microbiol Infect Dis. 2006 Aug;55(4):311-318. [PubMed] [CrossRef]
13. Tenover F. Rapid detection and identification of bacterial pathogens using novel molecular technologies: infection control and beyond. Clin Infect Dis. 2007 Feb;44(3):418-423. [PubMed] [CrossRef]
14. European Centre for Disease Prevention and Control, Summary of the latest data on antibiotic consumption in the European Union, 2014 Nov, Stockholm, 4 p [Internet].
Received: 09 March 2016
Published online: 31 May 2016