Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2016, vol. 22, issue 2
Subject Area: Medicine
Pages: 1136-1138
DOI: 10.5272/jimab.2016222.1136
Published online: 06 June 2016

J of IMAB 2016 Apr-Jun;22(2):1136-1138
Gabriela S. Tsankova1 Corresponding Autor, Zekie Kasimova2, Tatina T. Todorova1, Milena Avdzhiyska2, Dajna Tsankova2.
1) Department of Preclinical and Clinical Sciences, Faculty of Pharmacy, Medical University Varna, Bulgaria
2) Student in Medical University of Varna, Bulgaria.

Zika virus (ZIKV) is an arbovirus from Flaviviridae family, genus Flavivirus. Like most of the viruses which belong to the Flavivirus genus, it replicates in and is transmitted by mosquitoes. Unlike other arbovirus infections including dengue and chikungunya, Zika virus causes a relatively mild disease. The most common symptoms of ZIKV are mild fever, arthralgia, myalgia, headache, asthenia, abdominal pain, oedema, lymphadenopathy, retro-orbital pain, conjunctivitis, and cutaneous maculopapular rash, which last for several days to a week. Although 80% of the cases with ZIKV are asymptomatic, severe complications such as microcephalia and GBS may be observed. This explains why ZIKV is more dangerous that it was thought to be and why it rapidly evolves in unexpected challenge for the international and national public health authorities.

Key words: Zika virus, Pregnancy, Microcephaly, Guillain-Barré syndrome,

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Please cite this article in PubMed Style or AMA (American Medical Association) Style:
Tsankova GS, Kasimova Z, Todorova TT, Avdzhiyska M, Tsankova D. Outbreak of Zika virus disease and its complications. J of IMAB. 2016 Apr-Jun;22(2):1136-1138.

Correspondence to: Gabriela St. Tsankova, Department of Preclinical and Clinical Sciences, Faculty of Pharmacy, Medical University Varna; 3, Bregalniza Str., 9002 Varna, Bulgaria; E-mail:

1. Solomon T, Baylis M, Brown D. Zika virus and neurological disease-approaches to the unknown. Lancet Infect Dis. 2016 Apr;16(4):402-4. [PubMed] [CrossRef]
2. Smith DW, Mackenzie J. Zika virus and Guillain-Barrй syndrome: another viral cause to add to the list. Lancet. 2016 Apr;387 (10027):1486-8. [PubMed] [CrossRef]
3. World Health Organization. Zika virus microcephaly and guillain-barre syndrome. Situation report. 26 February 2016):1-12. [Internet]
4.  Petersen E, Wilson ME, Touch S, McCloskey B, Mwaba P, Bates M, et al. Unexpected and Rapid Spread of Zika Virus in The Americas - Implications for Public Health Preparedness for Mass Gatherings at the 2016 Brazil Olympic Games. Int J Infect Dis. 2016 Mar;44:11-15. [PubMed] [CrossRef]
5. Faye O, Faye O, Diallo D, Diallo M, Weidmann M, Sall AA. Quantitative real-time PCR detection of Zika virus and evaluation with field-caught mosquitoes. Virol J. 2013 Oct;10(1):311. [PubMed] [CrossRef]
6. Marano G, Pupella S, Vaglio S, Liumbruno GM, Grazzini G. Zika virus and the never-ending story of emerging pathogens and transfusion medicine. Blood Transfus. 2016 Mar;14(2):95-100. [PubMed] [CrossRef]
7. Sikka V, Chattu VK, Popli RK, Galwankar SC, Kelkar D, Sawicki SG, et al. The emergence of zika virus as a global health security threat: A review and a consensus statement of the INDUSEM Joint working Group (JWG). J Glob Infect Dis. 2016 Jan-Mar;8(1):3-15. [PubMed]
8.  Hennessey M, Fischer M, Staples JE. Zika Virus Spreads to New Areas — Region of the Americas, May 2015–January 2016. MMWR Morb Mortal Wkly Rep. 2016; 65place_Holder_For_Early_Release:55–58. [CrossRef]
9. Meaney-Delman D, Rasmussen SA, Staples JE, Oduyebo T, Ellington SR, Petersen EE, et al. Zika Virus and Pregnancy: What Obstetric Health Care Providers Need to Know. Obstet Gynecol. 2016 Apr;127(4):642-8. [PubMed] [CrossRef]
10. Besnard M, Lastиre S, Teissier A, Cao-Lormeau VM, Musso D. Evidence of perinatal transmission of zika virus, French Polynesia, December 2013 and February 2014. Euro Surveill. 2014 Apr;19(13): pii: 20751. [PubMed]
11. Foy BD, Kobylinski KC, Foy JLC, Blitvich BJ, da Rosa AT, Haddow AD, et al. Probable Non-Vector-borne Transmission of Zika Virus, Colorado, USA. Emerg Infect Dis. 2011 May;17(5):880-2. [PubMed] [CrossRef]
12. Musso D, Roche C, Robin E, Nhan T, Teissier A, Cao-Lormeau VM. Potential sexual transmission of Zika Virus. Emerg Infect Dis. 2015 Feb;21(2):359-61. [PubMed] [CrossRef]
13. ECDC. Rapid Risk Assessment. Zika virus disease epidemic/: potential association with microcephaly and Guillain-Barre syndrome (first ubdate) - 21 January 2016. [Internet]
14. Heymann DL, Hodgson A, Sall AA, Freedman DO, Staples JE, Althabe F, et al. Zika virus and microcephaly: why is this situation a PHEIC? Lancet. 2016 Feb;387(10020):719–21. [CrossRef]
15. Staples JE, Dziuban EJ, Fischer M, Cragan JD, Rasmussen SA, Cannon MJ, et al. Interim Guidelines for the Evaluation and Testing of Infants with Possible Congenital Zika Virus Infection - United States, 2016. MMWR Morb Mortal Wkly Rep. 2016 Jan;65(3):63–7.  [PubMed] [CrossRef]
16. Duffy MR, Chen T-H, Hancock WT, Powers AM, Kool JL, Lanciotti RS, et al. Zika virus outbreak on Yap Island, Federated States of Micronesia. N Engl J Med. 2009 Jun;360(24):2536-43. [PubMed] [CrossRef]
17. Mlakar J, Korva M, Tul N, Popovic M, Poljsak-Prijatelj M, Mraz J, et al. Zika Virus Associated with Microcephaly. N Engl J Med. 2016 Mar 10;374(10):951-8. [PubMed] [CrossRef]
18. Schuler-Faccini L, Ribeiro EM, Feitosa IML, Horovitz DDG, Cavalcanti DP, Pessoa A, et al. Possible Association Between Zika Virus Infection and Microcephaly - Brazil, 2015. MMWR Morb Mortal Wkly Rep. 2016 Jan;65(3):59-62. [CrossRef]
19. Cauchemez S, Besnard M, Bompard P, Dub T, Guillemette-artur P, Eyrolle-guignot D, et al. Articles Association between Zika virus and microcephaly in French Polynesia, 2013-15: a retrospective study. Lancet. 2016 May;387(10033):2125–2132. [CrossRef]
20. Ventura CV, Maia M, Bravo-Filho V, Gois AL, Belfort R Jr. Zika virus in Brazil and macular atrophy in a child with microcephaly. Lancet. 2016 Jan;387(10015):228. [PubMed] [CrossRef]
21. Triunfol M. Microcephaly in Brazil: confidence builds in Zika connection. Lancet Infect Dis. 2016;16(5):527–8. [CrossRef]
22. Petersen EE, Staples JE, Meaney-Delman D, Fischer M, Ellington SR, Callaghan WM, et al. Interim Guidelines for Pregnant Women During a Zika Virus Outbreak - United States, 2016. MMWR Morb Mortal Wkly Rep. 2016 Jan;65(2):30-3. [PubMed] [CrossRef]
23. World Health Organization. Pregnancy management in the context of Zika virus. Interim guidance. 2 March 2016.

Received: 18 April 2016
Published online: 06 June 2016

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