Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2016, vol. 22, issue 2
Subject Area: Medicine
Pages: 1160-1165
DOI: 10.5272/jimab.2016222.1160
Published online: 15 June 2016

J of IMAB 2016 Apr-Jun;22(2):1160-1165
Maya G. Lyapina1 Corresponding Autor, Mariana Tzekova2, Maria Dencheva2, Assya Krasteva2, Mariela Yaneva-Deliverska3, Angelina Kisselova2.
1) Department of Hygiene, Medical Ecology and Nutrition, Medical Faculty,
2) Department of Oral and Image Diagnostic, Faculty of Dental Medicine,
3) Department of Medical Ethics and Law, Faculty of Public Health,
Medical University - Sofia, Bulgaria.

The incorporation of nanoparticles into glass powder of glass ionomers led to wider particle size distribution, which resulted in higher mechanical values. Consequently they can occupy the empty spaces between the Glass ionomer particles and act as reinforcing material in the composition of the glass ionomer cements. The nanofiller components of nano ionomers also enhance some physical properties of the hardened restorative. Its bonding mechanism should be attributed to micro-mechanical interlocking provided by the surface roughness, most likely combined with chemical interaction through its acrylic/itaconic acid copolymers. The paper reviews their secondary caries prevention – fluoride release properties, mechanical and physical propreties, biocompatibility aspects, and antimicrobial activity.

Key words: nanodentistry, dental restorative materials, nano-glass-ionomer cements, biocompatibility aspects,

- Download FULL TEXT /PDF 547 KB/
Please cite this article in PubMed Style or AMA (American Medical Association) Style:
Lyapina MG, Tzekova M, Dencheva M, Krasteva A, Yaneva-Deliverska M, Kisselova A. Nano-glass-ionomer cements in modern restorative dentistry. J of IMAB. 2016 Apr-Jun;22(2):1160-1165. DOI:

Correspondence to: Maya Lyapina, MD, Department of Hygiene, Medical Ecology and Nutrition, Medical Faculty, Medical University – Sofia; 15, Acad. Ivan Evstr. Geshov Blvd ., 1431 Sofia, Bulgaria; E-mail:

1. Crisp S, Ferner AJ, Lewis BG, Wilson AD. Properties of improved glass-ionomer cement formulations. J Dent. 1975 May;3:125–30.
2. Katsuyama S, Ishikawa T, Fujii B. Glass ionomer dental cement: the materials and their clinical use. St. Louis, Tokyo: Ishiyaku EuroAmerican, 1993.
3. Wilson AD, Nicholson JW. Acid–base cements: their biomedical and industrial applications. Cambridge: Cambridge University Press, 1993. 398 p.
4. Nicholson JW. Chemistry of glass-ionomer cements: A review. Biomaterials. 1998 Mar;19:485–494.
5. Yip HK, Tay FR, Ngo H, Smales RJ, Pashley DH. Bonding of contemporary glass ionomer cements to dentin. Dent. Mater. 2001 Sep;17(5):456-470. [PubMed]
6. Xie D, Brantley WA, Culbertson BM, Wang G. Mechanical properties and microstructures of glass-ionomer cements. Dent. Mater. 2000 Mar;16(2):129-138. [PubMed]
7. Pelka M, Ebert J, Schneider H, Krämer N, Petschelt A. Comparison of two-and three-body wear of glass-ionomers and composites. Eur J Oral Sci. 1996 Apr;104:132–137.
8. Hickel R, Manhart J, Garcia-Godoy F. Clinical results and new developments of direct posterior restorations. Am J Dent. 2000 Nov;13(Spec No):41D-54D. [PubMed]
9. Kobayashi M, Kon M, Miyai K, Asaoka K. Strengthening of glass-ionomer cement by compounding short fibres with CaO-P2O5-SiO2-Al2O3 glass. Biomaterials. 2000 Nov-Dec;21: 2051-2058.
10. Lohbauer U, Walker J, Nikolaenko S, Werner J, Clare A, Petschelt A, Greil P. Reactive fiber reinorced glass ionomer cements. Biomaterials. 2003;24:2901–2907.
11. Wasson EA, Nicholson JW. New aspects of the setting of glass-ionomer cements. J. Dent. Res. 1993;72:481–483.
12. Moshaverinia A, Ansari S, Movasaghi Z, Billington RW, Darr JA, Rehman IU. Modification of conventional glass-ionomer cements with N-vinylpyrrolidone containing polyacids, nano-hydroxy and fluoroapatite to improve mechanical properties. Dental Mater. 2008;24:1381–1390.
13. Coutinho E, Cardoso MV, De Munck J, Neves AA, Van Landuyt KL, Poitevin A, et al. Bonding effectiveness and interfacial characterization of a nano-filled resin-modified glass-ionomer. Dent Mater. 2009;25:1347-57.
14. Chandki R, Kala M, Kumar NK, Brigit B, Banthia P, Banthia R. ‘NANODENTISTRY’: Exploring the beauty of miniature. J Clin Exp Dent. 2012 Apr;4(2):e119-24. [PubMed]
15. Sarrett DC. Clinical challenges and the relevance of materials testing for posterior composite restorations. Dent Mater. 2005;21:9-20.
16. Mjor IA, Moorhead JE, Dahl JE. Reasons for replacement of restorations in permanent teeth in general dental practice. Int Dent J. 2000 Dec;50:361-366.
17. Weigand A, Buchalla W, Attin T. Review on fluoride-releasing restorative materials—fluoride release and uptake characteristics, antibacterial activity and influence on caries formation. Dent Mater. 2007;23:343-362.
18. Xu X, Burgess JO. Compressive strength, fluoride release and recharge of fluoride-releasing materials. Biomaterials. 2003;24:2451-2461.
19. Itota T, Carrick TE, Yoshiyama M, McCabe JF. Fluoride release and recharge in glass giomer, compomer and resin composite. Dent Mater. 2004;20:789-795.
20. Anusavice KJ, Zhang NZ, Shen C. Effect of CaF2 content on rate of fluoride release from filled resins. J Dent Res. 2005 May;84:440-444.
21. Lin J, Zhu J, Gu X, Wen W, Li Q, Fischer-Brandies H, Wang H, Mehl C. Effects of incorporation of nano-fluorapatite or nano-fluorohydroxyapatite on a resin-modified glass ionomer cement. Acta Biomater. 2011 Mar;7(3):46-53. [PubMed]
22. Upadhyay S, Rao A, Shenoy R. Comparison of the amount of fluoride release from nanofilled resin modified glass ionomer, conventional and resin modified glass ionomer cements. J Dent (Tehran). 2013 Mar;10(2):134-40. [PubMed]
23. Sayyedan FS, Fathi M, Edris H, Doostmohammadi A, Mortazavi V, Shirani F. Fluoride release and bioactivity evaluation of glass ionomer: Forsterite nanocomposite. Dent Res J (Isfahan). 2013 Jul;10(4):452-9. [PubMed]
24. De Caluwé T, Vercruysse CW, Fraeyman S, Verbeeck RM. The influence of particle size and fluorine content of aluminosilicate glass on the glass ionomer cementproperties. Dent Mater. 2014 Sep;30(9):1029-38. [PubMed]
25. Nassar AM, Abdalla AI, Shalaby ME. One year clinical follow up of nano filled glass ionomer and composite resin restorations. Tanta Dental Journal. 2014 Apr;11:21-35.
26. Mu YB, Zang GX, Sun HC, Wang CK. Effect of nano-hydroxyapatite to glass ionomer cement. Hua Xi Kou Qiang Yi Xue Za Zhi. 2007 Dec;25(6):544-7.
27. Lee JJ, Lee YK, Choi BJ, Lee JH, Choi HJ, Son HK, Hwang JW, Kim SO. Physical properties of resin-reinforced glass ionomer cement modified with micro and nano-hydroxyapatite. J Nanosci Nanotechnol. 2010 Aug;10(8):5270-6.
28. de Paula AB, Fucio SB, Ambrosano GM, Alonso RC, Sardi JC, Puppin-Rontani RM. Biodegradation and abrasive wear of nano restorative materials. Oper Dent. 2011 Nov-Dec;36(6):670-7.
29. de Paula AB, de Fúcio SB, Alonso RC, Ambrosano GM, Puppin-Rontani RM. Influence of chemical degradation on the surface properties of nano restorative materials. Oper Dent. 2014 May-Jun;39(3):E109-17.
30. Joshi K, Dave B, Joshi N, Rajashekhara BS, Jobanputra LS, Yagnik K. Comparative Evaluation of Two Different Pit & Fissure Sealants and a Restorative Material to check their Microleakage - An In Vitro Study. J Int Oral Health. 2013 Aug;5(4):35-39.
31. Garcia-Contreras R, Scougall-Vilchis RJ, Contreras-Bulnes R, Kanda Y, Nakajima H, Sakagami H. Effects of TiO2 nano glass ionomer cements against normal and cancer oral cells. In Vivo. 2014 Sep-Oct;28(5):895-907. [PubMed]
32. Garcia-Contreras R, Scougall-Vilchis RJ, Contreras-Bulnes R, Kanda Y, Nakajima H, Sakagami H. Induction of prostaglandin E2 production by TiO2 nanoparticles in human gingival fibroblast. In Vivo. 2014 Mar-Apr;28(2):217-22. [PubMed]
33. Daugela P, Oziunas R, Zekonis G. Antibacterial potential of contemporary dental luting cements. Stomatologija. 2008;10(1):16–21.
34. Saku S, Kotake H, Scougall-Vilchis RJ, Ohashi S, Hotta M, Horiuchi S, et al. Antibacterial activity of composite resin with glass-ionomer filler particles. Dent Mater J. 2010 Mar;29(2):193-198. [PubMed]
35. Xie D, Weng Y, Guo X, Zhao J, Gregory RL, Zheng C. Preparation and evaluation of a novel glass-ionomer cement with antibacterial functions. Dent Mater. 2011 May;27(5):487-496. [PubMed]
36. Ahn SJ, Lee SJ, Kook JK, Lim BS. Experimental antimicrobial orthodontic adhesives using nanofillers and silver nanoparticles. Dent Mater. 2009;25(2):206– 213.
37. Magalhaes APR, Santos LB, Lopes LG, Estrela CRA, Estrela C, Torres EM, et al. Nanosilver application in dental cements. ISRN Nanotechnology. 2012 2012), Article ID 365438, 6 pages. [CrossRef]..

Received: 25 January 2016
Published online: 15 June 2016

back to Online Journal