Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2016, vol. 22, issue 3
Subject Area: Dental Medicine
Pages: 1212-1216
DOI: 10.5272/jimab.2016223.1212
Published online: 18 July 2016

J of IMAB 2016 Jul-Sep;22(3):1212-1216
TREATMENT OF ORAL MUCOSAL LESIONS BY SCALPEL EXCISION AND PLATELET-RICH FIBRINMEMBRANE GRAFTING: A case report
Ivan Chenchev Corresponding Autor, Radka Cholakova.
Department of Oral Surgery, Faculty of Dental Medicine, Medical University – Plovdiv, Bulgaria.

ABSTRACT:
Purpose: The treatment of oral mucosal lesions and mucosal hypertrophy in particular, is most often achieved by an excision with or without covering the surface of the wound. The platelet rich fibrin membrane (PRFm) is an autogenous product containing platelets and leukocytes and their secreted growth factors and cytokines. The purpose of the presented clinical case is to describe a new, recent technique used for the covering of mucosal wounds left after the removal of pathological lesions.
Material and Methods: On a single patient mucosal hypertrophy was removed by an excision with scalpel and the resulting surgical wound was covered with an autogenous PRF membrane. Postoperatively the healing process was followed on the 7th, 14th and 30th day.
Results: The healing period went smoothly with minimal postoperative discomfort and no complications.
Conclusion: The results of the presented clinical case demonstrate that the PRF membrane can successfully be used to cover postoperative mucosal defects.

Key words: oral mucosal hypertrophy, PRF, oral mucosal reconstruction,

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Please cite this article in PubMed Style or AMA (American Medical Association) Style:
Chenchev I, Cholakova R. Treatment of Oral Mucosal Lesions by Scalpel Excision and Platelet-Rich FibrinMembrane Grafting: A case report. J of IMAB. 2016 Jul-Sep;22(3):1212-1216.
DOI: http://dx.doi.org/10.5272/jimab.2016223.1212.

Correspondence to: Dr. Ivan Chenchev, Department of Oral Surgery, Faculty of Dental Medicine, Medical University – Plovdiv, Bulgaria; E-mail: ivan_chenchev@yahoo.com

REFERENCES:
1. van der Waal I. Potentially malignant disorders of the oral and oropharyngeal mucosa; terminology, classification and present concepts of management. Oral Oncol. 2009 Apr-May;45(4-5):317-23. [PubMed] [CrossRef]
2. Thomas G, Kunnambath R, Somanathan T, Mathew B, Pandey M, Rangaswamy S. Long-term outcome of surgical excision of leukoplakia in a screening intervention trial, Kerala, India.. J Indian Acad Oral Med Radiol. 2012; 24(2):126-129.
3. Yen DJ. Surgical treatment of submucous fibrosis. Oral Surg Oral Med Oral Pathol. 1982 Sep;54(3):269-72. [PubMed]
4.  Dohan Ehrenfest DM, Rasmusson L, Albrektsson T. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF). Trends Biotechnol. 2009 Mar; 27(3):158–67. [CrossRef]
5. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part III: leucocyte activation: a new feature for platelet concentrates? Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Mar;101(3):e51-5. [PubMed] [CrossRef]
6. Choukroun J, Adda F, Schoeffer C, Vervelle A. [PRF: an opportunity in perio-implantology] [in French]. Implantodontie. 2000; 42:55-62.
7. Dohan Ehrenfest DM, Del Corso M, Diss A, Mouhyi J, Charrier JB. Three-dimensional architecture and cell composition of a Choukroun's platelet-rich fibrin clot and membrane. J Periodontol.  2010 Apr;81(4):546-555. [PubMed]
8. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet-related biologic features. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Mar;101(3):e45-50. [PubMed] [CrossRef]
9. Dohan Ehrenfest DM, de Peppo GM, Doglioli P, Sammartino G. Slow release of growth factors and thrombospondin-1 in Choukroun’s platelet-rich fibrin (PRF): A gold standard to achieve for all surgical platelet concentrates technologies. Growth Factors. 2009 Feb;27(1):63-69. [PubMed]
10. Dohan Ehrenfest DM, Lemo N, Jimbo R, Sammartino G. Selecting a relevant animal model for testing the in vivo effects of Choukroun's platelet-rich fibrin (PRF): rabbit tricks and traps.. Oral Surg Oral Med Oral Pathol Oral RadiolEndod. 2010 Oct;110(4):413-6. [PubMed] [CrossRef]
11. Dohan Ehrenfest DM. How to optimize the preparation of leukocyte- and platelet-rich fibrin (L-PRF, Choukroun’s technique) clots and membranes: introducing the PRF Box. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Sep;110(3):275-8. [PubMed] [CrossRef]
12. Zhao JH, Tsai CH, Chang YC. Clinical and histologic evaluations of healing in an extraction socket filled with platelet-rich fibrin. J Dent Sci. 2011 Jun;6(2):116-122. [CrossRef]
13. Chang YC, Wu KC, Zhao JH. Clinical application of platelet-rich fibrin as the sole grafting material in periodontal intrabony defects. J Dent Sci. 2011 Sep;6(3):181-188. [CrossRef]
14. Zhao JH, Tsai CH, Chang YC. Management of radicular cysts using platelet-rich fibrin and bioactive glass: a report of two cases. J Formos Med Assoc. 2014 Jul;113(7): 470-6. [PubMed] [CrossRef]
15. Saluja H, Dehane V, Mahindra U. Platelet-Rich fibrin: A second generation platelet concentrate and a new friend of oral and maxillofacial surgeons. Ann Maxillofac Surg. 2011 Jan;1(1):53-7. [PubMed] [CrossRef]
16. Mohanty S, Pathak H, Dabas J. Platelet rich fibrin: A new covering material for oral mucosal defects. J Oral Biol Craniofac Res. 2014 May-Aug;4(2):144-6. [PubMed] [CrossRef]
17. Pathak H, Mohanty S, Urs AB, Dabas J. Treatment of Oral Mucosal Lesions by Scalpel Excision and Platelet-Rich Fibrin Membrane Grafting: A Review of 26 Sites. J Oral Maxillofac Surg. 2015 Sep; 73(9):1865-74. [PubMed] [CrossRef]
18. Kulkarni MR, Thomas BS, Varghese JM, Bhat GS. Platelet-rich fibrin as an adjunct to palatal wound healingafter harvesting a free gingival graft: A case series. J Indian Soc Periodontol. 2014 May;18(3):399-402. [PubMed] [CrossRef]
19. Shakir Q, Bhasale P, Pailwan N, Patil D. Comparison of Effects of PRF Dressing in Wound Healing of Palatal Donor Site During Free Gingival Grafting Procedures with No Dressing at the Donor Site. J Res Adv Dent 2015; 4:(1):69-74.

Received: 15 May 2016
Published online: 18 July 2016

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