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Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312 773X (Online)
Issue: 2016, vol. 22, issue 3
Subject Area: Dental Medicine
Pages: 1257-1260
DOI: 10.5272/jimab.2016223.1257
Published online: 08 August 2016
J of IMAB 2016 Jul-Sep;22(3):1257-1260
EFFECTIVENESS OF NON-SURGICAL PERIODONTAL THERAPY BY GINGIVAL EXPRESSION OF IL-1β AND IL-6
Antoaneta Mlachkova1 
, Velitchka Dosseva-Panova1, Christina Popova1, Maya Kicheva2
1) Department of Periodontology, Faculty of Dental Medicine, Medical University of Sofia, Bulgaria,
2) PhD, biochemist, Progene Ltd., Sofia, Bulgaria.
ABSTRACT:
Chronic periodontitis is a multifactorial disease that is characterized by attachment loss and loss of alveolar bone. Periodontal pathogens from the subgingival microbiota are suggested as a major etiological factor for the periodontitis. The host inflammatory response against bacteria and their virulence factors underlies the current understanding of the pathogenesis of chronic periodontitis. The destructive immune response was shown to be associated with an extremely increased production of inflammatory cytokines in periodontal tissues. The expression of several cytokines likeIL-1β and IL-6 is responsible for alveolar bone resorption, and loss of connective tissue attachment in chronic periodontitis.
Authors reported a reduction in the levels of inflammatory cytokines after successful periodontal therapy. Measuring the levels of inflammatory factors may be diagnostic approach to assess the effectiveness of the therapy of periodontitis.
Key words: chronic periodontitis, cytokines, IL-1β, IL-6, periodontal therapy, periodontal diagnosis,
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Please cite this article in PubMed Style or AMA (American Medical Association) Style:
Mlachkova A, Dosseva-Panova V, Popova C, Kicheva M. Effectiveness of non-surgical periodontal therapy by gingival expression of IL-1β and IL-6. J of IMAB. 2016 Jul-Sep;22(3):1257-1260
DOI: http://dx.doi.org/10.5272/jimab.2016223.1257.
Correspondence to: Antoaneta Mlachkova, Department of Periodontology, Faculty of Dental Medicine, Medical University – Sofia; 1, St. George Sofiiski Str., 1431 Sofia, Bulgaria; E-mail: dr_mlachkova@abv.bg
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Received: 08 June 2016
Published online: 08 August 2016