Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski, Gospodin Iliev ET
ISSN: 1312-773X (Online)
Issue: 2017, vol. 23, issue 1
Subject Area: Dental Medicine
Pages: 1447-1450
DOI: 10.5272/jimab.2017231.1447
Published online: 03 February 2017

J of IMAB 2017 Jan-Mar;23(1):1447-1450
Radka Cholakova1ORCID logo, Corresponding Autor, Martin Drangov1ORCID logo, Kremena Markova2ORCID logo, Viktoria Zidarova3, Martina Avramova3
1) Department of Oral Surgery, Faculty of Dental Medicine, Medical University – Plovdiv, Bulgaria
2) Department of Operative dentistry and Endodontics, Faculty of Dental Medicine, Medical University – Plovdiv, Bulgaria
3) Student, Faculty of Dental Medicine, Medical University – Plovdiv, Bulgaria.

Background:  Wilson’s disease is an autosomal recessive disorder due to mutation in ATB 7B gene, which is a membrane-bound copper-transporting ATPase. The impaired excretion of copper results in an increase in serum levels and accumulation of copper in the body. Various signs can be observed in liver, nervous system, kidneys, eyes, heart. There are also changes in blood chemistry.
Objective: A forty-six-year-old female patient presents with Wilson’s disease in the treatment rooms at the Faculty of Dentistry in Plovdiv. She needs complete dental care. She has also had an ischaemic stroke.
Methods and results: As the treatment plan started with extraction of teeth under local anaesthesia, a complete blood count and INR test were performed. Oral mucosa and bone were obtained by biopsy for evidence of pigments in these tissues. The biopsy results showed accumulation of copper in them as well.
Conclusion: It’s a rare disorder, approximately 1 in 40 000, severely affecting the liver and nervous system. It requires in-depth analysis and discussion over the clinical and paraclinical approach with a view to avoid possible complications and achieve the desired results.

Key words: morbus Wilson, INR, hemorrhagic stroke, Kayser-Fleischer ring,

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Please cite this article in PubMed Style or AMA (American Medical Association) Style:
Cholakova R, Drangov M, Markova K, Zidarova V, Avramova M. Surgical treatment in patients with Wilson’s disease. J of IMAB. 2017 Jan-Mar;23(1):1447-1450. DOI: 10.5272/jimab.2017231.1447.

For correspondence: Dr. Radka Cholakova, Department of Oral Surgery, Faculty of Dental Medicine, Medical University – Plovdiv, Bulgaria; E-mail:

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Received: 03 November 2016
Published online: 03 February 2017

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