Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski, Gospodin Iliev
ISSN: 1312-773X (Online)
Issue: 2017, vol. 23, issue 1
Subject Area: Dental Medicine
DOI: 10.5272/jimab.2017231.1495
Published online: 26 March 2017

Review Article

J of IMAB 2017 Jan-Mar;23(1):1495-1504
Elitsa G. DeliverskaORCID logoCorresponding Autor, Milena PetkovaORCID logo,
Department of Oral and Maxillo-Facial Surgery, Faculty of Dental Medicine, Medical University - Sofia, Bulgaria.

Oral leukoplakia is the most common potentially malignant disorder affecting oral cavity. Various surgical and non-surgical treatments have been reported, but currently there is no universal consensus on the most appropriate one and on the duration or interval of follow-up of patients with this condition.
The aim of this article is to present a review of the management of oral leukoplakia according to the literature until now.
 Management of oral leukoplakia should begin with elimination of risk factors (if any) such as tobacco abuse, betel chewing, alcohol abuse, superimposed candida infection over the lesion etc.
Conservative treatment includes use of chemopreventive agents such as vitamins (vitamins A, C, E), fenretinide (Vitamin A analogue), carotenoids (beta-carotene, lycopene), bleomycin, protease inhibitor, anti-inflammatory drugs, green tea, curcuma etc.
Surgical treatment includes conventional surgery, electrocoagulation, cryosurgery, and laser surgery (excision or evaporation). The main purpose of oral leukoplakia management is to avoid malignant transformation of the lesion or if this happened to detect this in early stages.

Key words: Leukoplakia, management, surgical, non-surgical treatment,

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Please cite this article in PubMed Style or AMA (American Medical Association) Style:
Deliverska EG, Petkova M. Management of Oral Leukoplakia - Analysis of the Literature. J of IMAB. 2017 Jan-Mar;23(1):1495-1504. DOI: 10.5272/jimab.2017231.1495.

For correspondence: Elitsa G. Deliverska, Department of Oral and Maxillofacial surgery, Faculty of Dental Medicine, Medical University - Sofia, Bulgaria; 1, St. Georgi Sofiiski str., 1431 Sofia, Bulgaria. ; E-mail:

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Received: 25 January 2017
Published online: 26 March 2017

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