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Publisher: Peytchinski Publishing
ISSN: 1312-773X (Online)
Issue: 2017, vol. 23, issue 2
Subject Area: Medicine - Toxicology
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DOI: 10.5272/jimab.2017232.1541
Published online: 10 May 2017
Original Article
J of IMAB 2017 Apr-Jun;23(2):1541-1545
CLINICAL CRITERIA FOR THE OUTCOME FORECAST OF ACUTE EXOGENOUS INTOXICATIONS WITH ORGANOPHOSPHORUS PESTICIDES
Petko Marinov1, 3, Snezha Zlateva1, 3, Dobri Ivanov2, Georgi Bonchev1
, Yulichka Sabeva3, Kaloyan Georgiev4, Ivaylo Vazharov5
1) Clinic for Intensive Treatment of Acute Intoxications and Toxicoallergies, Naval Hospital – Varna, Military Medical Academy, Bulgaria
2) Department of Biology, Faculty of Pharmacy, Medical University – Varna, Bulgaria
3) Department of Pharmacology, Toxicology and Pharmacotherapy, Faculty of Pharmacy, Medical University – Varna, Bulgaria
4) Department of Pharmaceutical Technologies, Faculty of Pharmacy, Medical University – Varna, Bulgaria
5) Clinic of Internal Diseases, Naval Hospital – Varna, Military Medical Academy, Bulgaria.
ABSTRACT:
Purpose: The wide-spread use of organophosphorus pesticides (OPP) and their substantial toxicity determine the high frequency of poisoning with them. Despite the modern treatment methods, the acute exogenous intoxications (AEI) continue to exhibit high lethality and are the source of one of the most serious problems in the clinical toxicology. A number of not commonly accepted criteria have been suggested to estimate the gravity of the organophosphorous intoxication. Until now no system of clinical criteria exists that would forecast the outcome of this type of acute poisoning. The aim of this study is to develop an outcome forecast of AEI with OPP with the help of basic clinical criteria.
Materials/Methods: The subjects of the study are 160 patients. We explore the significance of five of the most typical clinical indicators of the acute poisoning with OPP for the outcome of the intoxication and the need of artificial pulmonary ventilation, with the aid of discriminatory statistical analysis. The selected indicators form a discriminatory model with automatically built discrimination function.
Results: The obtained classification coefficients allow us to construct a forecast matrix containing score estimates designed for practical applications.
Keywords: organophosphorus pesticides, acute poisoning, prognosis,
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Please cite this article in PubMed Style or AMA (American Medical Association) Style:
Marinov P, Zlateva S, Ivanov D, Bonchev G, Sabeva Y, Georgiev K, Vazharov I. Clinical criteria for the outcome forecast of acute exogenous intoxication with organophosphorus pesticides. J of IMAB. 2017 Jan-Mar;23(2):1541-1545. DOI: 10.5272/jimab.2017232.1541
Correspondence to: Georgi Bonchev, PhD, Head, Laboratory of Analytical Toxicology, Military Medical Academy, Naval Hospital – Varna; 3, Hristo Smirnenski Blvd., 9010 Varna, Bulgaria; E-mail: toxilab.varna@abv.bg
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Received: 16 March 2017
Published online: 10 May 2017