ADRENALECTOMY FOR ISOLATED METASTASES

Svetlana Shumarova; Damyan Petrov; Konstantin Grozdev; Anatoli Semkov; Danail Petrov; George Todorov

doi:10.5272/jimab.2017233.1651

Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski Publishing
ISSN: 1312-773X (Online)
Issue: 2017, vol. 23, issue 3
Subject Area: Medicine
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DOI: 10.5272/jimab.2017233.1651
Published online: 17 August 2017

Original article

J of IMAB 2017 Jul-Sep;23(3):1651-1656
ADRENALECTOMY FOR ISOLATED METASTASES
Svetlana Shumarova¹ , Damyan Petrov², Konstantin Grozdev¹, Anatoli Semkov¹, Danail Petrov³, George Todorov¹
1) Department of Surgery, University Hospital Aleksandrovska Sofia, Bulgaria, Medical University, Sofia, Bulgaria
2) Department of Social Medicine and Health Management, Medical Faculty, Trakia University, Stara Zagora, Bulgaria
3) Department of Thoracic Surgery, Saint Sophia Hospital for Pulmonary Diseases, Sofia, Bulgaria.

ABSTRACT:
Background: Isolated adrenal gland metastases are not frequently finding. The aim of the present retrospective study was to estimate clinical and pathological parameters that could be used to predict survival after adrenalectomy.
Material and methods: A total of 34 patients with adrenal gland masses suspected to be metastases was included in this study. The group of patients with isolated metastases was19 (56%) and a group of patients with adrenal adenomas -15 (44%).
Results: The sample of patients consisted of 18 (53%) men and 16 (47%) women from 40 to 81 years old with a mean (±SD) age of 61.6±10.3 years, presented with adrenal mass suspected to be metastases. Nineteen (56%) of them had demonstrated metastases and 16 (84%) metachronous with median overall survival (OS) 54.6 (range 43-66) months. Median OS in the group with metastases was 22.6 months. Lung carcinoma was the most common primary tumour metastasizing in the adrenal gland – 58% of all metastases with a disease-free interval (DFI) of 13 months. It was presented by shorter median survival than the rest primary tumour types (37.8 vs. 96.7months; log-rank test, p=0.028). In the multivariate Cox’s hazard analysis of the surgical technique was found to be an independent prognostic factor (p=0.047), together with lung carcinoma vs. renal cell carcinoma (p=0.045).
Conclusion: Adrenalectomy due to isolated metastases in the adrenal glands showed the median overall survival of 22.6 months. Shorter survival periods were associated with lung carcinoma, DFI<12months, conversion to open surgery, synchronous metastases, but not with age, tumour size or resection status.

Keywords: adrenal gland, adrenal metastases, adrenalectomy, laparoscopic adrenalectomy,

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Please cite this article in PubMed Style or AMA (American Medical Association) Style:
Shumarova S, Petrov D, Grozdev K, Semkov A, Petrov D, Todorov G. Adrenalectomy for isolated metastases. J of IMAB. 2017 Jul-Sep;23(3):1651-1656. DOI: 10.5272/jimab.2017233.1651

Correspondence to: Svetlana Shumarova, Department of Surgery, University Hospital “Aleksandrovska” Sofia, Medical University Sofia; 1, St. Georgi Sofijski Blvd, 1431 Sofia, Bulgaria; E-mail: svetla_arn@abv.bg

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Received: 27 May 2017
Published online: 17 August 2017

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