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Publisher: Peytchinski Publishing
ISSN: 1312-773X (Online)
Issue: 2017, vol. 23, issue 4
Subject Area: Medicine
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DOI: 10.5272/jimab.2017234.1823
Published online: 15 December 2017
Review article
J of IMAB 2017 Oct-Dec;23(4):1823-1827
PECULIARITIES AT CLINICAL COURSE AND PROGNOSTIC FACTORS OF THE MOST COMMON VIRAL INFECTIONS OF THE CENTRAL NERVOUS SYSTEM
Liliya Pekova
,
Clinic of Infectious Diseases, University Multiprofile Hospital for active treatment, Stara Zagora
Section of Infectious Diseases, Department of Hygiene, Infectious Diseases and Epidemiology, Medical Faculty, Trakia University, Stara Zagora, Bulgaria.
ABSTRACT:
Viral infections of the central nervous system (CNS) are highly varied and in many cases difficult for diagnostics. Recently they have become more frequent in the practice of the specialists in infectious diseases and general medicine. Sometimes they had a motley clinical spectrum in other cases they were so similar that their appearance was a big challenge for clinicians.
The aim of this presentation was to clarify the peculiarities in clinical course and prognostic factors of some of the most widespread viral CNS infections.
In Bulgaria, 400 cases of viral infections of the CNS were registered per annum. The most prevalent of them were caused by Enteroviruses. Encephalitis, caused by Herpes simplex virus type 1 (HSV1) was associated with high mortality and severe residual complications in survivors. VZV provoked benign encephalitis with cerebellitis. Lymphocytic choriomeningitis virus meningitis was characterized with long-lasting meningeal signs and combined with some psychological deviations and focal neurological disorders. Influenza virus rare but serious affected CNS with convulsions, psychotic expressions, stupor and coma.
Prognosis for the severity of viral infections of the CNS was dependent on age, immune status, neurological predisposition and virulence of the etiological agent. Some peculiarities at laboratorial findings, as well as the delaying of specific etiological therapy were important prognostic factors for bad outcome.
Keywords: viral infections of CNS, peculiarities, prognostic factors,
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Please cite this article in PubMed Style or AMA (American Medical Association) Style:
Pekova L. Peculiarities at clinical course and prognostic factors of the most common viral infections of the central nervous system. J of IMAB. 2017 Oct-Dec;23(4):1823-1827. DOI: 10.5272/jimab.2017234.1823
Correspondence to: Prof. Liliya Pekova, Department of Hygiene, Infectious Diseases and Epidemiology, Medical Faculty, Trakia University, Stara Zagora; 11, Armeyska Str., Stara Zagora, Bulgaria; E-mail: pe_kova@abv.bg
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Received: 24 July 2017
Published online: 15 December 2017