head JofIMAB
Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2019, vol. 25, issue2
Subject Area: Medicine
DOI: 10.5272/jimab.2019252.2544
Published online: 08 May 2019

Original article

J of IMAB. 2019 Apr-Jun;25(2):2544-2548
Miroslav D. Marinov1ORCID logo Corresponding Autoremail, Margarita S. Velikova2ORCID logo, Roman E. Tashev3ORCID logo, Dobrinka K. Doncheva2ORCID logo,
1) Department of Physiology and Pathophysiology, Union of Pathophysiology, Faculty of Medicine, Medical University of Varna, Bulgaria.
2) Department of Physiology and Pathophysiology, Union of Physiology, Faculty of Medicine, Medical University of Varna, Bulgaria.
3 Department of Pathophysiology, Medical University of Sofia; Institute of Neurobiology, Bulgarian Academy of Sciences, Bulgaria.

Purpose: The endocannabinoid system is considered a key regulatory system in anxiety behavior. The aim of the present study was to examine the effects of intracerebroventricularly (i.c.v.) injected cannabinoid ligands on the anxiety-like behavior of rats with a model of depression.
Material/Methods: The olfactory bulbectomized rat (OBX) is a well-established experimental model of depression. The OBX model exhibits neurochemical changes that are very similar to those seen in patients with depression. CB1 receptor agonist HU-210 and CB1 receptor antagonist SR 141716A were injected i.c.v. in OBX rats, and the anxiety-related behavior of the rats was measured in an elevated plus-maze (EPM) test.
Results: OBX rats showed an increased anxiety-like behavior at the EPM test. HU-210 produced an anxiolytic-like effect and alleviated the OBX-induced anxiety, while SR 141716A failed to produce effects on the behavior of OBX rats.
Conclusions: The results suggest that CB1 receptors may be involved in the modulation of anxiety-related behavior in OBX rats.

Keywords: Endocannabinoid system, Olfactory bulbectomy, Anxiety, Depression, HU-210, SR 141716A,

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Please cite this article as: Marinov MD, Velikova MS, Tashev RE, Doncheva DK. Modulatory effect of cannabinoid ligands on the anxiety-like behavior of bulbectomized rats. J of IMAB. 2019 Apr-Jun;25(2):2544-2548. DOI: 10.5272/jimab.2019252.2544

Corresponding AutorCorrespondence to: Dr Miroslav Dimitrov Marinov, Department of Physiology and Pathophysiology, Medical University - Varna; 55, Marin Drinov str., 9002 Varna, Bulgaria; E-mail: miroslav.marinov@mu-varna.bg

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Received: 25 September 2018
Published online: 08 May 2019

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