Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski Publishing Ltd.
ISSN:
1312-773X (Online)
Issue:
2019, vol. 25, issue2
Subject Area:
Medicine
-
DOI:
10.5272/jimab.2019252.2589
Published online: 27 June 2019
Original article

J of IMAB. 2019 Apr-Jun;25(2):2589-2594
DETERMINATION OF PHENOLIC COMPOUNDS IN PRUNUS DOMESTICA FRUITS EXTRACT AND ITS PHARMACOLOGICAL ACTIVITY
Shahm B. Mohammed1
, Taras V. Upyr2
, Olga M. Shapoval3
, Larysa V. Lenchyk1


, Kaloyan Georgiev4
,
1) Department of Chemistry of Natural Compounds, National University of Pharmacy, Kharkiv, Ukraine,
2) Department of Pharmacognosy, National University of Pharmacy, Kharkiv, Ukraine
3) Department of Pharmacology and Prescription writing, Kharkiv National Medical University Kharkiv, Ukraine
4) Department of Pharmaceutical technologies, Faculty of pharmacy, Medical University of Varna, Bulgaria.
ABSTRACT:
Qualitative composition and content of phenolic compounds in the liquid extract obtained from plum fruits have been studied. Five phenolic substances were found, as gallic acid, three hydroxycinnamic acids and rutin. The dominant substance was neochlorogenic acid (2320±42 mg/kg). Phenolic substances were identified in the extract and their amount determined by HPLC. Diuretic activity as diurnal spontaneous diuresis and forced diuresis, hypouricosemic and the membrane-stabilizing effects of plum liquid extract and its influence on the rheological properties of blood were studied.
Keywords: plum, fruits, extract, phenolic compounds, diuretic, hypouricosemic, membrane-stabilizing effect,
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Please cite this article as: Mohammed SB, Upyr TV, Olga M. Shapoval OM, Lenchyk LV, Georgiev K. Determination of phenolic compounds in Prunus domestica fruits extract and its pharmacological activity. J of IMAB. 2019 Apr-Jun;25(2):2589-2594. DOI: 10.5272/jimab.2019252.2589
Correspondence to: Larysa Lenchyk, Chemistry of Natural Compounds Department, National University of Pharmacy; 53, Pushkinska str., Kharkiv 61002, Ukraine; E-mail: larysa.lenchyk@gmail.com
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Received: 29 November 2018
Published online: 27 June 2019
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