head JofIMAB
Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2019, vol. 25, issue4
Subject Area: Medicine
DOI: 10.5272/jimab.2019254.2755
Published online: 04 November 2019

Original article

J of IMAB. 2019 Oct-Dec;25(4):2755-2758;
Zhivka Stoykova1, 2ORCID logo Corresponding Autoremail,
1) Laboratory of Virology, University Hospital St. Marina - Varna, Bulgaria
2) Department of Microbiology and Virology, Medical University of Varna, Bulgaria.

Prenatal cytomegalovirus (CMV) screening is not routinely conducted in Bulgaria. According to our previous data, CMV infection is widespread in our region with a total seroprevalence of 78.4%. Such high seroprevalence may have profound effect over the incidence of congenital CMV (cCMV) infections. We aimed in determination of the serological CMV status of both women in reproductive age and pregnant women.
Materials and methods:
Retrospective: 1612 women in childbearing age (15-49 y)
Prospective: 121 pregnant women (14-41 y)
ELISA tests for detection of anti-CMV IgM/IgG and for avidity determination of anti-CMV IgG, EUROIMMUN, Germany.
Results: From a total of 1612 women in childbearing age, 1362 (84.5%, 95% CI: 82.73 - 86.27) were anti-CMV IgG positive.
From a total of 121 pregnant women, 105 (86.8%, 95% CI: 80.77 - 92.83) were anti CMV IgG positive and 12 (9.9%, 95% CI: 4.58 - 15.22%) were anti CMV IgM positive. We got a high IgG avidity index in all seropositive pregnant women, including those with IgM positive results.
Conclusions: CMV infection is highly prevalent in women in reproductive age in Bulgaria and the estimated hypothetical population transmission risk in our region is a total of 7%.
We compared the preliminary retrospective data with the data obtained from a real situation of 121 pregnancies and got very similar results. Since almost 10% of the pregnant women had evidence of acute or recent infection, this required us to perform the anti-CMV IgG avidity test. We got a high IgG avidity index in all pregnant women.

Keywords: CMV, serological screening, reproductive age, pregnancy, ELISA,

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Please cite this article as: Stoykova Zh. Serological CMV screening in women of reproductive age and in pregnant women. J of IMAB. 2019 Oct-Dec;25(4):2755-2758. DOI: 10.5272/jimab.2019254.2755

Corresponding AutorCorrespondence to: Zhivka Stoykova, MD, PhD, Laboratory of Virology, University Hospital St. Marina, Varna; 1, Hristo Smirnenski Blvd, 9010, Varna, Bulgaria; E-mail: jivita77@abv.bg

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Received: 19 March 2019
Published online: 04 November 2019

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