head JofIMAB
Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2020, vol. 26, issue1
Subject Area: Medicine
DOI: 10.5272/jimab.2020261.2936
Published online: 24 February 2020

Original article

J of IMAB. 2020 Jan-Mar;26(1):2936-2941
Margarita Velikova1ORCID logo Corresponding Autoremail, Dobrinka Doncheva1ORCID logo, Roman Tashev2ORCID logo,
1) Department of Physiology and pathophysiology, Medical University-Varna, Bulgaria.
2) Department of Pathophysiology, Medical University -Sofia, Bulgaria.

The abnormal activity of endocannabinoid system has been implicated in the mechanisms of some psychiatric and neurological disorders. Olfactory bulbectomy (OBX) is an animal model of depression. We examined the effect of the CB1 antagonist Rimonabant (RIM) on the learning and memory processes of OBX rats tested in an active avoidance paradigm. RIM was administeredbyintragastric cannula to OBX rats once daily for 14 days. OBX rats were divided into three groups, and RIM was given before; immediately after; or 14 days after OBX. RIM showed a memory enhancing effect in the sham-operated rats and partially ameliorated the memory disturbances induced by the bulbectomy, given before OBX or 14 days after OBX. Only upon administration immediately after OBX, it prevented the development of the memory deficits.  The study provides evidence that impaired endocannabinoid signalling may be involved in the development of cognitive deficits accompanying the OBX syndrome.

Keywords: Olfactory bulbectomy, cannabinoid receptor, memory, rat,

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Please cite this article as: Velikova M, Doncheva D, Tashev R. Effects of Rimonabant on active avoidance learning in bulbectomized rats. J of IMAB. 2020 Jan-Mar;26(1):2936-2941. DOI: 10.5272/jimab.2020261.2936

Corresponding AutorCorrespondence to: Assoc. prof. Margarita Velikova, MD, PhD, Department of Physiology and Pathophysiology, Medical University; 55, M. Drinov Str., 9002 Varna, Bulgaria; E-mail: msvelikova@yahoo.com

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Received: 13 January 2020
Published online: 24 February 2020

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