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Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2020, vol. 26, issue1
Subject Area: Medicine
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DOI: 10.5272/jimab.2020261.3011
Published online: 27 March 2020
Original article
J of IMAB. 2020 Jan-Mar;26(1):3011-3014
ASSESSMENT OF VITAMIN D STATUS AND CALCIUM-PHOSPHORUS METABOLISM IN POSTMENOPAUSAL WOMEN WITH OSTEOPOROSIS
Tatyana Simeonova1
, Krasimira Stefanova2, Ivelina Himcheva1, Pavlina Yordanova-Laleva3, Boryana Ruseva1, Aneliya Dimitrova1,
1) Department of Physiology and Pathophysiology, Medical University - Pleven, Bulgaria.
2) Diagnostic Consulting Center II - Pleven, Bulgaria.
3) Faculty of Pharmacy, Medical University-Pleven, Bulgaria.
ABSTRACT:
his study aims to assess vitamin D levels in women with postmenopausal osteoporosis and healthy women in menopause. Two groups of women over 50 years of age took part in the study – 41 women with osteoporosis and 22 without osteoporosis. The levels of vitamin D, parathormone, alkaline phosphatase, calcium and phosphorus were examined.
16 women with osteoporosis (39%) were with normal levels of vitamin D, 14 (34,1%) were with insufficiency, and 11 (26,9%) with deficiency of vitamin D. Within the control group, 8 women (36,4%) were with normal levels of vitamin D, 12 (54,5%) were with vitamin D insufficiency and 2 (9,1%) with deficiency.
The patients with vitamin D deficiency were significantly older both in the osteoporosis group and the control group (r = -0.32, p<0.05). A negative correlation with the increase of parathormone levels among the patients with osteoporosis and vit D deficiency was found (r = -0.46, p<0.01). There is a significant statistical difference in the average values of BMI in both groups. The average value of BMI in the patients with osteoporosis is 24.2 while in the patients of the control group, it’s 29.5 (p<0.0001). The same trend is seen in the patients with vitamin D deficiency both in the women with and the women without osteoporosis (24.4 to 28.2, respectively, p<0.05). The results show an overall bad status of vitamin D. 61% of the patients with osteoporosis and 63,6 % of the healthy controls have levels of vitamin D, showing either insufficiency or deficiency.
Keywords: postmenopausal osteoporosis, insufficiency and deficiency of vitamin D,
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Please cite this article as: Simeonova T, Stefanova K, Himcheva I, Yordanova-Laleva P, Ruseva B, Dimitrova A. Assessment of vitamin D status and calcium-phosphorus metabolism in postmenopausal women with osteoporosis. J of IMAB. 2020 Jan-Mar;26(1):3011-3014.
DOI: 10.5272/jimab.2020261.3011
Correspondence to: Tatyana N. Simeonova, Department of Physiology and Pathological Physiology, Medical University-Pleven; 1, St. Kliment Ohridski str., Pleven, 5800, Bulgaria; E-mail: dr_tsimeonova@abv.bg
REFERENCES:
1. Bulgarian Society of Endocrinology. [Recommendations for good clinical practice in osteoporosis.] Sofia, 2019: 12. [in Bulgarian]
2. Krasimirova D, Petrova D, Georgiev O, Cherneva R. Vitamin D the known and unknown. Thoracic Medicine 2016; 8(1):58-75.
3. Borissova A-M, Shinkov A, Vlahov J, Dakovska L, Todorov T, Svinarov D, et al. [Determination of the Optimal Level of 25(OH)D in the Bulgarian Population.] Еndocrinologia. 2012; 17(3):135-42. [in Bulgarian]
4. Bulgarian Society of Endocrinology. [Recommendations for diagnosis, prevention and treatment of vitamin D deficiency and insufficiency.] Sofia 2019:18 [in Bulgarian]
5. Gerdhem P, Ringsberg KAM, Obrant KJ, Akesson K. Association Between 25-hydroxy Vitamin D Levels, Physical Activity, Muscle Strength and Fractures in the Prospective Population-Based OPRA Study of Elderly Women. Osteoporos Int. 2005 Nov;16(11):1425-31. [PubMed] [Crossref]
6. Napoli N,Thompson J, Civitelli R, Armamento-Villareal RC. Effects of Dietary Calcium Compared With Calcium Supplements on Estrogen Metabolism and Bone Mineral Density. Am J Clin Nutr. 2007 May;85(5):1428-33. [PubMed] [Crossref]
7. Borissova A-M, Shinkov A, Vlahov J, Dakovska L, Todorov T, Svinarov D, et al. Vitamin D status in Bulgaria-winter data. Arch Osteoporos. 2013 Dec;8:133. [PubMed] [Crossref]
8. Borissova A-M, Shinkov A, Vlahov J, Dakovska L, Todorov T, Svinarov D, et al. [Frequency of Deficiency, Insufficiency and Sufficiency of Vitamin D in Bulgarian Population (≥20-80 years old).] Еndocrinologia, 2012 Jan; 17(3):122-134. [in Bulgarian].
Received: 13 June 2019
Published online: 27 March 2020