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Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2020, vol. 26, issue2
Subject Area: Medicine
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DOI: 10.5272/jimab.2020262.3053
Published online: 02 April 2020
Case report
J of IMAB. 2020 Apr-Jun;26(2):3053-3056
VARICELLA ZOSTER VIRUS ASSOCIATED ASEPTIC MENINGITIS IN AN IMMUNOCOMPETENT PATIENT
Zhivka Stoykova1, 2
, Tsvetelina Kostadinova1, 3, Radka Argirova4,
1) Laboratory of Virology,” St. Marina” University Hospital – Varna, Bulgaria
2) Department of Microbiology and Virology, Medical University of Varna, Bulgaria
3) Medical College, Medical University of Varna, Bulgaria
4) Clinical Laboratory, Acibadem City Clinic Tokuda Hospital, Sofia, Bulgaria.
ABSTRACT:
Background: Varicella zoster virus (VZV) is a widespread herpes virus that causes chickenpox after primary infection. Later the virus remains persistent in the sensory nerve ganglia, and it can be reactivated with the manifestation of herpes zoster most often. But reactivation of VZV can manifest as infection of the CNS (central nervous system) even in an immunocompetent host. The detection of VZV Ab by ELISA and VZV-DNA in cerebrospinal fluid by PCR has improved the laboratory conformation of that condition in an immunocompetent host with discreet exanthema.
Materials and Methods: Two serum samples and three CSF samples of a patient with aseptic meningitis were tested by ELISA and PCR.
Interpretation: This clinical case demonstrates that VZV may be considered in all cases of aseptic meningitis even in immunocompetent individuals without the typical rash. In cases under VZV associated meningitis suspicion, the first detection marker to be positive is VZV-DNA and later anti-VZV IgG in CSF.
Keywords: VZV, VZV reactivation, VZV-DNA in CSF, aseptic meningitis,
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Please cite this article as: Stoykova Z, Kostadinova T, Argirova R. Varicella zoster virus associated aseptic meningitis in an immunocompetent patient. J of IMAB. 2020 Apr-Jun;26(2):3053-3056. DOI: 10.5272/jimab.2020262.3053
Correspondence to: Zhivka Stoykova, Laboratory of Virology, University Hospital St. Marina, Varna; 1, Hristo Smirnenski Blvd., 9010, Varna, Bulgaria; E-mail: jivita77@abv.bg
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Received: 24 June 2019
Published online: 02 April 2020