head JofIMAB
Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2020, vol. 26, issue3
Subject Area: Pharmacy
DOI: 10.5272/jimab.2020263.3226
Published online: 08 July 2020

Review article

J of IMAB. 2020 Jul-Sep;26(3):3226-3233
Ivaylo PehlivanovORCID logo Corresponding Autoremail,
Department of Pharmaceutical Technologies, Faculty of Pharmacy, Medical University, Varna, Bulgaria.

There is a great number of active pharmaceutical ingredients (APIs) in development that have low solubility and/or low permeability. The oral administration is usually connected with low bioavailability, high Intra- and inter- variability of the plasma levels and lack of dose proportionality. Formulating such APIs in SEDDS ameliorates the solubility, permeability and bioavailability profiles with reproducible plasma concentrations. SEDDS are mixtures of different oils and emulgators, ideally isotropic mixtures. Often they contain co-emulsifiers and co-solvents. After dispersion in the gastric fluids, they self-emulsify to fine O/W or W/O/W emulsions having dimensions of the dispersed phase in the range 100-300 nm and in some cases under 100nm. Surfactants’ concentration, surfactant to oil ratio, emulsion polarity, droplet dimension and surface charge are important parameters that influence API absorption from SEDDS when orally administered. These Drug Delivery Systems can facilitate permeation process, but preferable absorption path is through the lymphatic system that leads to bypassing the hepatic first-pass metabolism. The use of in-vitro dispersion and digestion methods permit to  a better understanding of the role of the processes that the lipids undergo in the gastrointestinal tract (GIT) during the solubilization of these systems.
The aim of the article is to present a short overview of SEDDS as a strategy to bioavailability improvement, basic principles of excipient selection during their formulation and their characterisation.

Keywords: lipid-based drug delivery systems, SEDDS, SMEDDS, SNEDDS,

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Please cite this article as: Pehlivanov I. Self-Emulsifying Drug Delivery Systems (SEDDS): Excipient selection, formulation and characterization. J of IMAB. 2020 Jul-Sep;26(3):3226-3233. DOI: 10.5272/jimab.2020263.3226

Corresponding AutorCorrespondence to: Ivaylo Pehlivanov, Department of Pharmaceutical Technologies, Faculty of Pharmacy, Medical University of Varna; 84, Tzar Osvoboditel str. – Medical College building, room 314 B., 9000 Varna, Bulgaria E-mail: Ivaylo.Pehlivanov@mu-varna.bg

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Received: 20 August 2019
Published online: 08 July 2020

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