head JofIMAB
Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2021, vol. 27, issue1
Subject Area: Medicine
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DOI: 10.5272/jimab.2021271.3543
Published online: 22 January 2021

Original article

J of IMAB. 2021 Jan-Mar;27(1):3543-3548
RISK FACTORS IN PATIENTS WITH BISPHOSPHONATE - ASSOCIATED OSTEONECROSIS OF THE JAWS
Meri Hristamyan1ORCID logo Corresponding Autoremail, Ralitsa Raycheva2ORCID logo, Petia Pechalova3ORCID logo, Veselka Hristamyan4ORCID logo, Yordanka Stoilova1ORCID logo,
1) Department of Epidemiology and DM, Faculty of Public Health, Medical University - Plovdiv, Bulgaria
2) Department of Social Medicine, Faculty of Public Health, Medical University - Plovdiv, Bulgaria
3) Department of Oral Surgery, Faculty of Dental Medicine, Medical University - Plovdiv, Bulgaria
4) Clinic of Maxillo-facial Surgery, UMHAT "St. George" - Plovdiv, Bulgaria.

ABSTRACT:
Purpose: To investigate patient diagnosed with BAONJ in order to identify the presence of risk factors.
Material/Methods: A prospective epidemiological study of 112 patients diagnosed with Bisphosphonate-associated Osteonecrosis of the jaw in 2016 and 2017 was conducted in the Clinic of maxillo-facial surgery of UMHAT "St. George", Plovdiv, Bulgaria, based on anamnesis, clinical examination, hospital documentation, and imaging studies. SPSS Statistics v.24 was used for statistical analysis, at a significance level p<0.05.
Results: Of the patients, 77.89% had a primary oncological diagnosis of breast or prostate cancer; the average duration of bisphosphonate therapy up to the time of the study is 4.5 years; the most common co-morbidities were hypertension (72.73%), anemia (40.00%) and diabetes (23.67%); 65.18% of patients smoke or are former smokers; the time till first oral complaints after initiation of BP treatment was usually 2 years (31.25%, n = 35) and 3 years (24.11%, n = 27) (p> 0.05).; the last dental manipulation before the onset of symptoms was tooth extraction (52.68%), followed by removable dentures (21.42%).
Conclusions: The investigation of identified in the literature risk factors with their occurrence in the studied population shows a correlation with the data of leading researchers.

Keywords: bisphosphonates, Osteonecrosis, risk factors, oncology, epidemiology,

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Please cite this article as: Hristamyan M, Raycheva R, Pechalova P, Hristamyan V, Stoilova Y. Risk Factors in Patients with Bisphosphonate - Associated Osteonecrosis of the Jaws. J of IMAB. 2021 Jan-Mar;27(1):3543-3548. DOI: 10.5272/jimab.2021271.3543

Corresponding AutorCorrespondence to: Dr Meri Hristamyan, PhD, Department of Epidemiology and DM, Faculty of Public Health, Medical University – Plovdiv; 15A, Vasil Aprilov Str., Plovdiv, Bulgaria; E-mail: mary_hr@abv.bg

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Received: 05 December 2019
Published online: 22 January 2021

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