head JofIMAB
Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2021, vol. 27, issue1
Subject Area: Medicine
DOI: 10.5272/jimab.2021271.3634
Published online: 25 March 2021

Original article

J of IMAB. 2021 Jan-Mar;27(1):3634-3642
Milena Pasheva1ORCID logo, Yoto Yotov2ORCID logo, Miglena Nikolova1ORCID logo, Daniela Gerova3ORCID logo, Atanas Angelov2ORCID logo, Bistra Galunska1ORCID logo Corresponding Autoremail,
1) Department of Biochemistry, Molecular medicine and Nutrigenomics, Faculty of Pharmacy, Medical University, Varna, Bulgaria.
2) First Department of Internal Diseases, Faculty of Medicine, Medical University, Varna, Bulgaria.
3) Department of General Medicine and Clinical Laboratory, Faculty of Medicine, Medical University, Varna, Bulgaria.

Purpose: To assess the role of asymptomatic hyperuricemia for the presence and severity of coronary arterial calcium (CAC) in adults with different cardiovascular (CV) pathology and its association with conventional CV risk factors.
Material/Methods: Adults (n=81) of both genders were divided into controls: with moderate- to high risk without known CVD; AF-group: CVD-patients with paroxysmal or persistent atrial fibrillation in sinus rhythm, HF–group: heart failure subjects with preserved ejection fraction. A structured interview was performed at admittance for evaluation of the classical CVD risk factors. CAC score (CACS) was determined by multislice computed tomography. Routine laboratory parameters, including uric acid (UA), were extracted from medical documentation.
Descriptive statistics, Mann-Whitney U-test, one-way ANOVA, chi-square test, Spearman's correlation, and multiple linear regression analysis were applied. The predictive power of serum UA was evaluated using receiver operating characteristic (ROC) analysis. Statistical significance was considered at p<0.05.
Results: Serum UA was significantly higher in subjects with CACS=1-99AU (p=0.030), and with CACS≥100AU (p=0.067) vs. patients without CACS. Within the UA tertiles, highest CACS was found in the tertile with highest serum UA. UA revealed positive relation with CACS (r=0.35, p=0.002), age (r=0.25, p=0.027), body mass index (0.27, p=0.017), waist circumference (r=0.44, p<0.0001), triglycerides (r=0.29, p=0.001), and creatinine (r=0.54, p<0.0001). Multiple linear regression analysis revealed significant association between UA as dependent variable and waist circumference (β=0.63, p=0.061), serum triglycerides (β=0.37, p=0.028), creatinine levels (β=0.45, p<0.0001).
Conclusions: Asymptomatic hyperuricaemia could be an important metabolic factor negatively affecting the chronic cardio-vascular pathology besides the conventional risk factors.

Keywords: uric acid, cardiovascular diseases, coronary arterial calcification,

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Please cite this article as: Pasheva M, Yotov Y, Nikolova M, Gerova D, Angelov A, Galunska B. Asymptomatic hyperuricemia as a potential metabolic risk factor for coronary artery calcification in patients with atrial fibrillation or heart failure. J of IMAB. 2021 Jan-Mar;27(1):3634-3642. DOI: 10.5272/jimab.2021271.3634

Corresponding AutorCorrespondence to: Bistra Galunska, Department of Biochemistry, Molecular medicine and Nutrigenomics, Medical University, Varna; 55 Marin Drinov, 9002 Varna, Bulgaria; E-mail: bistra.galunska@gmail.com

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Received: 14 December 2020
Published online: 25 March 2021

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