 |
Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2021, vol. 27, issue4
Subject Area: Medicine
-
DOI: 10.5272/jimab.2021274.3999
Published online: 04 October 2021
Review article
J of IMAB. 2021 Oct-Dec;27(4):3999-4003
OZONE FEATURES IN THE CONTEXT OF ADVANCING COVID-19 PANDEMIC
Galina Yaneva1
, Dobri Ivanov1, Diana Ivanova2 
,
1) Department of Biology, Faculty of Pharmacy, Medical University, Varna, Bulgaria.
2) Department of Biochemistry, Molecular Medicine and Nutrigenomics, Faculty of Pharmacy, Medical University, Varna, Bulgaria.
ABSTRACT:
Coronavirus disease 2019 represents a serious challenge for modern society worldwide because of the considerable and unfavourable consequences of the pandemic in terms of human health, economics and social life. In the present survey, some essential peculiarities of ozone as an air pollutant and powerful oxidant under the conditions of the COVID-19 pandemic as reflected in the recent literature are described. The understanding of ozone chemistry during COVID-19 lockdown can improve ozone parameterization in models of chemical transport. Ozone peroxides such as ozonides, aldehydes, hydrogen peroxides, and organic peroxide serve as messengers to modulate the human immune system and improve blood rheology.
Keywords: COVID-19 pandemic, ozone, air pollution, ozone oxidation,
- Download FULL TEXT /PDF 517 KB/
Please cite this article as: Yaneva G, Ivanov D, Ivanova D. Ozone features in the context of advancing COVID-19 pandemic. J of IMAB. 2021 Oct-Dec;27(4):3999-4003. DOI: 10.5272/jimab.2021274.3999
Correspondence to: Prof. Diana Ivanova, PhD, DSc, Department of Biochemistry, Molecular Medicine and Nutrigenomics, Faculty of Pharmacy, Medical University of Varna; 84 Tsar Osvoboditel Blvd., 9002 Varna, Bulgaria; E-mail: divanova@mu-varna.bg
REFERENCES:
1. Alsharef A, Banerjee S, Uddin SMJ, Albert A, Jaselskis E. Early impacts of the COVID-19 pandemic on the United States construction industry. Int J Environ Res Public Health. 2021 Feb 6;18(4):1559. [PubMed]
2. Elvis AM, Ekta JS. Ozone therapy: a clinical review. J Nat Sci Biol Med. 2011 Jan;2(1):66-70. [PubMed]
3. Cross CE, Reznick AZ, Packer L, Davis PA, Suzuki YJ, Halliwell B. Oxidative damage to human plasma proteins by ozone. Free Radic Res Commun. 1992;15(6):347-52. [PubMed]
4. Zoran MA, Savastru RS, Savastru DM, Tautan MN. Assessing the relationship between ground levels of ozone (O3) and nitrogen dioxide (NO2) with coronavirus (COVID-19) in Milan, Italy. Sci Total Environ. 2020 Oct 20;740:140005. [PubMed]
5. Di Mauro R, Cantarella G, Bernardini R, Di Rosa M, Barbagallo I, Distefano A, et al. The biochemical and pharmacological properties of ozone: the smell of protection in acute and chronic diseases. Int J Mol Sci. 2019 Feb;20(3):634. [PubMed]
6. Isaifan RJ. The dramatic impact of Coronavirus outbreak on air quality: Has it saved as much as it has killed so far? Glob J Environ Sci Manag. 2020;6(3):275-288. [Crossref]
7. Arias Velásquez RM, Mejía Lara JV. Gaussian approach for probability and correlation between the number of COVID-19 cases and the air pollution in Lima. Urban Climate. 2020 Sep;33:100664. [PubMed]
8. Connerton P, Vicente de Assunção J, Maura de Miranda R, Dorothée Slovic A, José Pérez-Martínez P, Ribeiro H. Air quality during COVID-19 in four megacities: Lessons and challenges for public health. Int J Environ Res Public Health. 2020 Jul;17(14):5067. [PubMed]
9. Fronza R, Lusic M, Schmidt M, Lucic B. Spatial-temporal variations in atmospheric factors contribute to SARS-CoV-2 outbreak. Viruses. 2020 May;12(6):588. [PubMed]
10. Ong SWX, Tan YK, Chia PY, Lee TH, Ng OT, Wong MSY, et al. Air, surface environmental, and personal protective equipment contamination by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from a symptomatic patient. JAMA. 2020 Apr;323(16):1610-1612. [PubMed]
11. Dantas G, Siciliano B, França BB, da Silva CM, Arbilla G. The impact of COVID-19 partial lockdown on the air quality of the city of Rio de Janeiro, Brazil. Sci Total Environ. 2020 Aug 10;729:139085. [PubMed]
12. Sharma S, Zhang M, Anshika JG, Gao J, Zhang H, Kota SH. Effect of restricted emissions during COVID-19 on air quality in India. Sci Total Environ. 2020 Aug 1;728:138878. [PubMed]
13. Ran J, Zhao S, Han L, Chen D, Yang Z, Yang L, et al. The ambient ozone and COVID-19 transmissibility in China: A data-driven ecological study of 154 cities. J Infect. 2020 Sep;81(3):e9-e11. [PubMed]
14. Coccia M. Factors determining the diffusion of COVID-19 and suggested strategy to prevent future accelerated viral infectivity similar to COVID. Sci Total Environ. 2020 Aug 10;729:138474. [PubMed]
15. Adhikari A, Yin J. Short-term effects of ambient ozone, PM (2.5) and meteorological factors on COVID-19 confirmed cases and deaths in Queens, New York. Int J Environ Res Public Health. 2020 Jun;17(11):4047. [PubMed]
16. Zhao YB, Zhang K, Xu XT, Shen HZ, Zhu X, Zhang YX, et al. Substantial changes in nitrogen dioxide and ozone after excluding meteorological impacts during the COVID-19 outbreak in mainland China. Environ Sci Technol Lett. 2020 May 18;7(6):402-408. [PMC]
17. Siciliano B, Dantas G, da Silva CM, Arbilla G. Increased ozone levels during the COVID-19 lockdown: Analysis for the city of Rio de Janeiro, Brazil. Sci Total Environ. 2020 Oct 1;737:139765. [PubMed]
18. Aydın S, Nakiyingi BA, Esmen C, Güneysu S, Ejjada M. Environmental impact of coronavirus (COVID-19) from Turkish perceptive. Environ Dev Sustain. 2020 Aug 13;1-8. [PubMed]
19. Sicard P, De Marco A, Agathokleous E, Feng Z, Xu X, Paoletti E, et al. Amplified ozone pollution in cities during the COVID-19 lockdown. Sci Total Environ. 2020 Sep 15;735:139542. [PubMed]
20. Ryan RG, Silver JD, Schofield R. Air quality and health impact of 2019-20 Black Summer megafires and COVID-19 lockdown in Melbourne and Sydney, Australia. Environ Pollut. 2021 Apr 1;274:116498. [PubMed]
21. Tripepi G, Plebani M, Iervasi G, Gori M, Leonardis D, D'Arrigo G, et al. Distance from the outbreak of infection, ozone pollution and public health consequences of SARS-CoV-2 epidemic: the HOPE method. Eur J Public Health. 2021 Feb 1;31(1):7-12. [PubMed]
22. Rathod A, Sahu SK, Singh S, Beig G. Anomalous behaviour of ozone under COVID-19 and explicit diagnosis of O3-NOxVOCs mechanism. Heliyon. 2021 Feb;7(2):e06142. [PubMed]
23. Bocci V. Ozone: A new medical drug. 2nd ed. Dordrecht, Springer. 2011, pp. XXI, 315. [Crossref]
24. Jiang HJ, Chen N, Shen ZQ, Yin J, Qiu ZG, Miao J, et al. Inactivation of poliovirus by ozone and the impact of ozone on the viral genome. Biomed Environ Sci. 2019 May;32(5):324-333. [PubMed]
25. Valdenassi L, Franzini M, Ricevuti G, Rinaldi L, Galoforo AC, Tirelli U. Potential mechanisms by which the oxygen-ozone (O2-O3) therapy could contribute to the treatment against the coronavirus COVID-19. Eur Rev Med Pharmacol Sci. 2020 Apr;24(8):4059-4061. [PubMed]
26. Air quality guidelines. Global update 2005. Geneva: WHO Europe. 2006. [Internet]
27. Integrated Science Assessment (ISA) for Ozone and Related Photochemical Oxidants (Final Report, Apr 2020). US. EPA. Apr 20, 2020. [Internet]
28. Bocci V. Ozonization of blood for the therapy of viral diseases and immunodeficiencies: A hypothesis. Med Hypotheses. 1992 Sep;39(1):30-4. [PubMed]
29. Babior BM, Takeuchi C, Ruedi J, Gutierrez A, Wentworth P Jr. Investigating antibody-catalyzed ozone generation by human neutrophils. Proc Natl Acad Sci USA. 2003 Mar 18;100(6):3031-4. [PubMed]
30. Lu QB. Reaction cycles of halogen species in the immune defense: Implications for human health and diseases and the pathology and treatment of COVID-19. Cells. 2020 Jun 13;9(6):1461. [PubMed]
31. Villarreal DO, Weiner DB. IL-33 isoforms: their future as vaccine adjuvants? Expert Rev Vaccines. 2015 Apr;14(4):489-92. [PubMed]
32. Mathews JA, Krishnamoorthy N, Kasahara D, Cho Y, Wurmbrand AP, Ribeiro L, et al. IL-33 drives augmented responses to ozone in obese mice. Environ Health Perspect. 2017 Feb;125(2):246-253. [PubMed]
33. Kurai J, Onuma K, Sano H, Okada F, Watanabe M. Ozone augments interleukin-8 production induced by ambient particulate matter. Genes Environ. 2018 Jul 18;40:14. [PubMed]
34. Pecorelli A, Bocci V, Acquaviva A, Belmonte G, Gardi C, Virgili F, et al. NRF2 activation is involved in ozonated human serum upregulation of HO-1 in endothelial cells. Toxicol Appl Pharmacol. 2013 Feb 15;267(1):30-40. [PubMed]
35. Delgado-Roche L, Riera-Romo M, Mesta F, Hernandez-Matos Y, Barrios JM, Martinez-Sanchez G, et al. Medical ozone promotes Nrf2 phosphorylation reducing oxidative stress and proinflammatory cytokines in multiple sclerosis patients. Eur J Pharmacol. 2017 Sep 15;811:148-154. [PubMed]
36. Galie M, Covi V, Tabaracci G, Malatesta M. The role of Nrf2 in the antioxidant cellular response to medical ozone exposure. Int J Mol Sci. 2019 Aug 17;20(16):4009. [PubMed]
37. Semple JL, Moore GWK. High levels of ambient ozone (O3) may impact COVID-19 in high altitude mountain environments. Respir Physiol Neurobiol. 2020 Sep;280:103487. [PubMed]
38. Rowen RJ, Robins HR. A plausible "penny" costing effective treatment for corona virus - ozone therapy. J Infect Dis Epidemiol. 2020 Mar;6(2):113. [Crossref]
39. Xia Y, Niu Y, Cai J, Lin Z, Liu C, Li H, et al. Effects of personal short-term exposure to ambient ozone on blood pressure and vascular endothelial function: a mechanistic study based on DNA methylation and metabolomics. Environ Sci Technol. 2018 Nov 6;52(21):12774-12782. [PubMed]
40. Mehraban F, Seyedarabi A, Seraj Z, Ahmadian S, Poursasan N, Rayati S, et al. Molecular insights into the effect of ozone on human hemoglobin in autohemotherapy: Highlighting the importance of the presence of blood antioxidants during ozonation. Int J Biol Macromol. 2018 Nov;119:1276-1285. [PubMed]..
Received: 04 March 2021
Published online: 04 October 2021