head JofIMAB
Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2022, vol. 28, issue1
Subject Area: Medicine
DOI: 10.5272/jimab.2022281.4289
Published online: 21 March 2022

Case report
J of IMAB. 2022 Jan-Mar;28(1):4289-4291
Klimentina GospodinovaORCID logo Corresponding Autoremail, Dimitar GospodinovORCID logo,
Department of Dermatology, Venereology and Allergology, Medical University, Pleven, Bulgaria.

Currently in Bulgaria the two messenger RNA vaccines used to vaccinate the population against COVID-19 are Pfizer-BioNTech COVID-19 Vaccine (COMIRNATY) and Moderna COVID-19 Vaccine. We present a case of a patient with palmoplantar form of psoriasis (in remission in the last 2 years), who has an attack of psoriasis of the nails, which began two weeks after the second dose of Pfizer-BioNTech COVID-19 Vaccine. Within the next two months, onychopathy of the nails of the ten fingers developed with the manifestation of almost all known psoriatic changes in the nail bed and nail matrix. The toenails are not affected. Topical therapy with calcipotriol/betamethasone ointment under occlusive dressings was prescribed for two months. The monitoring continues.

Keywords: messenger RNA vaccine, nail psoriasis, Nail Psoriasis Severity Index,

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Please cite this article as: Gospodinova K, Gospodinov D. New onset of nail psoriasis after mRNA COVID-19 vaccine: a case report. J of IMAB. 2022 Jan-Mar;28(1):4289-4291.
DOI: 10.5272/jimab.2022281.4289

Corresponding AutorCorrespondence to: Klimentina Gospodinova, MD, PhD, Department of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University, Pleven; 91, General Vladimir Vazov Str., 5800 Pleven, Bulgaria; E-mail: klimentina_gospodinova@abv.bg

1. Bogdanov G, Bogdanov I, Kazandjieva J, Tsankov N. Cutaneous adverse effects of the available COVID‐19 vaccines. Clin Dermatol. 2021 May-Jun;39(3):523-531. [PubMed]
2. McMahon DE, Amerson E, Rosenbach M, Lipoff JB, Moustafa D, Tyagi A, et al. Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: A registry-based study of 414 cases. J Am Acad Dermatol. 2021 Jul;85(1):46-55. [PubMed]
3. Bellinato F, Maurelli M, Gisondi P, Girolomoni G. Cutaneous Adverse Reactions Associated with SARS-CoV-2 Vaccines. J Clin Med. 2021 Nov 16;10(22):5344. [PubMed]
4. Macias VC, Cunha D. Psoriasis triggered by tetanus-diphtheria vaccination. Cutan Ocul Toxicol. 2013 Jun;32(2): 164-5. [PubMed]
5. Yoneyama S, Kamiya K, Kishimoto M, Komine M, Ohtsuki M. Generalized exacerbation of psoriasis vulgaris induced by pneumococcal polysaccharide vaccine. J Dermatol. 2019 Nov;46(11):e442–e443. [PubMed]
6. de Barros MH, Avelleira JCR, Mendes KAP. Impact of yellow fever vaccine on patients with psoriasis: preliminary results. An Bras Dermatol. 2019 Nov-Dec;94 (6):757-759. [PubMed]
7. Munguıa-Calzada P, Drake-Monfort M, Armesto S, Reguero-Del Cura L, Lopez-Sundh AE, Gonzalez-Lopez MA. Psoriasis flare after influenza vaccination in Covid-19 era: a report of four cases from a single center. Dermatol Ther 2021 Jan;34(1):e14684. [PubMed]
8. Sahin U, Muik A, Derhovanessian E, Vogler I, Kranz LM, Vormehr M, et al. COVID-19 vaccine BNT162b1elicits human antibody and TH1 T cell responses. Nature. 2020 Oct;586(7830): 594-599. [PubMed]
9. Krajewski PK, Matusiak Ł, Szepietowski JC. Psoriasis flare-up associated with second dose of Pfizer-BioNTech BNT16B2b2 COVID-19 mRNA vaccine. J Eur Acad Dermatol Venereol. 2021 Oct;35(10):e632-e634. [PubMed]
10. Sotiriou E, Tsentemeidou A, Bakirtzi K, Lallas A, Ioannides D, Vakirlis E. Psoriasis exacerbation after COVID-19 vaccination: a report of 14 cases from a single centre. J Eur Acad Dermatol Venereol. 2021 Dec;35(12):e857-e859. [PubMed]
11. Ricardo JW, Lipner SR. Case of de novo nail psoriasis triggered by the second dose of Pfizer-BioNTech BNT162b2 COVID-19 messenger RNA vaccine. JAAD Case Rep. 2021 Nov;17:18-20. [PubMed]
12. Egeberg A, See K, Garrelts A, Russel Burge R. Epidemiology of psoriasis in hard-to-treat body locations: data from the Danish skin cohort. BMC Dermatol. 2020 May 20;20(1):3. [PubMed]
13. Merola JF, Li T, Li W-Q, Cho E, Qureshi AA. Prevalence of psoriasis phenotypes among men and women in the USA. Clin Exp Dermatol. 2016 Jul;41(5):486-9. [PubMed]
14. Griffiths CEM, Armstrong AW, Gudjonsson JE, Barker JNWN. Psoriasis. Lancet. 2021 Apr 3;397(10281):1301-1315. [PubMed]
15. Gospodinov D, Tisheva S. [Psoriatic arthritis as a form of comorbidity]. Dematologia i venerologia Sofia. 2013; 51 (2):9-16. [in Bulgarian].

Received: 04 November 2021
Published online: 21 March 2022

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