head JofIMAB
Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2022, vol. 28, issue3
Subject Area: Medicine
DOI: 10.5272/jimab.2022283.4461
Published online: 20 July 2022

Original article
J of IMAB. 2022 Jul-Sep;28(3):4461-4464
Pavlina Glogovska1ORCID logo Corresponding Autoremail, Konstantin Gospodinov2ORCID logo, Plamen Pavlov1ORCID logo, Elena Borisova1ORCID logo,
1) Clinic of Pneumology and Phthisiatry, Medical University, Pleven, Bulgaria.
2) First Cardiology Clinic, Medical University, Pleven, Bulgaria.

Purpose: to analyze the epidemiological and clinical parameters of asthmatic patients with COVID-19 infection.
Materials and methods: a retrospective study was performed including data from an outpatient pulmonary practice in Pleven, Bulgaria, for the period 01.04. 2020 – 31.12. 2021. Sixty-five asthmatics were included and divided into two groups, referred to hospital due to COVID-19 infection (A) and outpatients (B), and their epidemiological and clinical data were compared.
Results: 65 patients were analyzed, 46 (71%) women and 19 (29%) men. Forty-four patients were confirmed with PCR and/or antigen test, and in 21, the diagnosis was based on clinical and X-ray data. Group A included 18 patients. It was found that patients over 65 years were significantly more in group A (44.4% vs 18.8%, p<0.05). There were significant differences between the groups concerning ischemic heart disease (9%/3%, p=0.001), arterial hypertension (10.6%/7.6%, p=0.007), heart failure (3%/0%, p=0.01), diabetes, but not in allergic rhinitis. We did not find a distinction regarding sex, adherence to inhalation therapy and usage of systemic corticosteroids (p>0.05). None of the patients had an exacerbation during the treatment in the hospital and within a month after the hospital discharge.
Conclusion: According to the analyses of the study, COVID-19 infection is not a risk factor for asthma exacerbations. The leading causes for the severity of the coronavirus infection in asthmatics are the age and some concomitant diseases.

Keywords: asthma, COVID-19, outpatients, comorbidities,

pdf - Download FULL TEXT /PDF 630 KB/
Please cite this article as: Glogovska G, Gospodinov K, Pavlov P, Borisova E. Epidemiological and clinical parameters in patients with COVID-19 and bronchial asthma. J of IMAB. 2022 Jul-Sep;28(3):4461-4464. DOI: 10.5272/jimab.2022283.4461

Corresponding AutorCorrespondence to: Assoc. prof. Pavlina Glogovska, MD PhD, Clinic of Pneumology and Phthisiatry, Medical University, Pleven; 81, Gen. Vladimir Vazov Str., Pleven, Bulgaria; E-mail: pglogovska@gmail.com

1. Soriano JB, Kendrick PJ, Paulson KR, Gupta V, Abrams EM, Adedoyin RA, et al. prevalence and attributable health burden of chronic respiratory diseases, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Respir Med. 2020 Jun;8(6):585-596. [PubMed]
2. 2022 GINA Report, Global Strategy for Asthma Management and Prevention. [Internet]
3. Izquierdo JL, Almonacid C, González Y, Del Rio-Bermudez C, Ancochea J, Cárdenas R, et al. The impact of COVID-19 on patients with asthma. Eur Respir J. 2021 Mar 4;57(3):2003142. [PubMed]
4. Zhu Z, Hasegawa K, Ma B, Fujiogi M, Camargo CA Jr, Liang L. Association of asthma and its genetic predisposition with the risk of severe COVID-19. J Allergy Clin Immunol. 2020 Aug;146(2):327-329.e4. [PubMed]
5. Gutiérrez-Gutiérrez B, Del Toro MD, Borobia AM, Carcas A, Jarrín I, Yllescas M, et al. Identification and validation of clinical phenotypes with prognostic implications in patients admitted to hospital with COVID-19: a multicentre cohort study. Lancet Infect Dis. 2021 Jun;21(6):783-792. [PubMed]
6. Philip KEJ, Buttery S,Williams P, Vijayakumar B, Tonkin J, Cumella A, et al. Impact of COVID-19 on people with asthma: a mixed methods analysis from a UK wide survey. BMJ Open Resp Res. 2022 Jan;9(1):e001056. [PubMed]
7. Nicholson KG, Kent J, Ireland DC. Respiratory viruses and exacerbations of asthma in adults. BMJ. 1993 Oct 16;307(6910):982-6. [PubMed]
8. Hopkinson NS, Jenkins G, Hart N. COVID-19 and what comes after? Thorax. 2021 Apr;76(4):324-325. [PubMed]
9. Williamson EJ, Walker AJ, Bhaskaran K, Bacon S, Bates C, Morton CE, et al. Factors associated with COVID-19-related death using OpenSAFELY. Nature. 2020 Aug;584(7821):430-436. [PubMed]
10. Davies G, Alsallakh M, Sivakumaran S, Vasileiou E, Lyons R, Robertson C, et al. Impact of COVID-19 lockdown on emergency asthma admissions and deaths: national interrupted time series analyses for Scotland and Wales. Thorax. 2021 Sep;76(9):867–873. [PubMed]
11. Halpin DMG, Faner R, Sibila O, Badia JR, Agusti A. Do chronic respiratory diseases or their treatment affect the risk of SARS-CoV-2 infection? Lancet Respir Med. 2020 May;8(5):436-438. [PubMed]
12. Gern JE, Busse WW. Relationship of viral infections to wheezing illnesses and asthma. Nat Rev Immunol. 2002 Feb;2(2):132-8. [PubMed]
13. Heffler E, Detoraki A, Contoli M, Papi A, Giovanni P, Malipiero G, et al. COVID-19 in Severe Asthma Network in Italy (SANI) patients: Clinical features, impact of comorbidities and treatments. Allergy. 2021 Mar;76(3)887-892. [PubMed]
14. Sanyaolu A, Okorie C, Marinkovic A, Patidar R, Younis K, Desai P, et al. Comorbidity and its Impact on Patients with COVID-19. SN Compr Clin Med. 2020; 2(8):1069-1076. [PubMed]
15. Singh AK, Gupta R, Ghosh A, Misra A. Diabetes in COVID-19: prevalence, pathophysiology, prognosis, and practical considerations. Diabetes Metab Syndr. 2020 Jul-Aug;14(4):303–310. [PubMed]
16. Zhao Q, Meng M, Kumar R, Wu Y, Huang J, Ningfang L, et al. The impact of COPD and smoking history on the severity of COVID-19: a systemic review and meta-analysis. J Med Virol. 2020 Oct;92(10):1915-1921. [PubMed]
17. Schultze A, Douglas I. COVID-19 and inhaled corticosteroids-another piece in an expanding puzzle. Lancet Respir Med. 2021 Jul;9(7):674-675. [PubMed]

Received: 18 January 2022
Published online: 20 July 2022

back to Online Journal