head JofIMAB
Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2022, vol. 28, issue3
Subject Area: Medicine
DOI: 10.5272/jimab.2022283.4525
Published online: 29 August 2022

Original article
J of IMAB. 2022 Jul-Sep;28(3):4525-4531
Edhem Hasković1,ORCID logo, Safija Herenda2ORCID logo Corresponding Autoremail, Amina Herenda1,ORCID logo, Denis Hasković3,ORCID logo, Ena Hasković 4,ORCID logo, Amina Selimović5,ORCID logo,
1) Department of Biology, Faculty of Science, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
2) Department of Chemistry, Faculty of Science, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
3) Clinical Center, University of Sarajevo, Organizational unit clinical pathology, cytology and human genetics, Sarajevo, Bosnia and Herzegovina.
4) Clinical Center, University of Sarajevo, Organizational unit clinical biochemistry with immunology, Sarajevo, Bosnia and Herzegovina.
5) Clinical Center, University of Sarajevo, Pediatric Clinic, Sarajevo, Bosnia and Herzegovina.

Glucocorticoids prevent or suppress the full inflammatory response to the infectious, immunological or physical agents by inhibiting early inflammatory events such as edema or cell exudation. The main effect of glucocorticoids on the inflammatory process is the inhibition or recruitment of neutrophils and monocytes. In this study, the effect of the glucocorticoid betamethasone on the hematological parameters of rats of the species Rattus norvegicus Berkenhout 1769 was examined in vivo. Betamethasone has been shown to affect the values of hematological parameters four hours after application and leads to a significant decrease in the prevalence of lymphocytes and monocytes, but also leads to a statistically significant increase in erythrocyte count, hemoglobin concentration and hematocrit values.

Keywords: Glucocorticoid, hematology, in vivo condition,

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Please cite this article as: Haskovic E, Herenda S, Herenda A, Haskovic D, Haskovic E, Selimovic A. Effects of drug betamethasone on hematological parameters of Rattus norvegicus (Berkenhout 1769) in vivo conditions. J of IMAB. 2022 Jul-Sep;28(3):4525-4531.
DOI: 10.5272/jimab.2022283.4525

Corresponding AutorCorrespondence to: Dr Safija Herenda, Assoc. Prof., Department of Chemistry, Faculty of Science, University of Sarajevo; Zmaja od Bosne 33-35, Sarajevo, Bosnia and Herzegovina; E-mail: islamovic.safija@gmail.com

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Received: 22 November 2021
Published online: 29 August 2022

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