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Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2022, vol. 28, issue4
Subject Area: Dental Medicine
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DOI: 10.5272/jimab.2022284.4634
Published online: 25 October 2022
Original article
J of IMAB. 2022 Oct-Dec;28(4):4634-4639
APPLICATION OF PLATELET RICH FIBRIN IN SURGICAL PERIODONTAL THERAPY: A CONTROLLED CLINICAL TRIAL
Antoaneta Mlachkova1
, Velitchka Dosseva-Panova1, Ivan Ivanov1, Dimitar Parvanov2, Hristina Maynalovska1,
1) Faculty of Dental Medicine, Department of Periodontology, Medical University - Sofia, Bulgaria.
2) Nadezhda Women's Health Hospital, Research Department, Sofia, Bulgaria.
ABSTRACT:
Purpose: The current study investigates the effectiveness of two surgical protocols for the treatment of periodontitis (Stage III or Stage IV) in the presence of angular bone defects.
Materials and methods: Twenty patients diagnosed with periodontitis were randomly divided into two groups, each of 10 patients with radiographically proven infraosseous defects. The first group delivered surgical treatment with bone graft and platelet rich fibrin, the second group – only with bone graft. Clinical and radiographic parameters were assessed before and 6 months after the surgical procedure.
Results: Statistically significant differences were found between both groups in the following parameters: probing pocket depth, clinical attachment gain, bone filling, and radiographic depth of the bone defect before and after periodontal surgery, described as bone filling in millimeters.
Conclusion: The results show platelet rich fibrin as an autogenous material with promising potential. Its additional application to bone replacement materials can improve the clinical parameters and the expected filling of the vertical bone defects.
Keywords: growth factors, periodontal regeneration, periodontitis, platelet-rich fibrin, platelet-rich plasma,
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Please cite this article as: Mlachkova A, Dosseva-Panova V, Ivanov I, Parvanov D, Maynalovska H. Application of platelet rich fibrin in surgical periodontal therapy: a controlled clinical trial. J of IMAB. 2022 Oct-Dec;28(4):4634-4639. DOI: 10.5272/jimab.2022284.4634
Correspondence to: Assoc. Prof. Antoaneta Mlachkova, Head of Department of Periodontology, Faculty of Dental Medicine, Medical University – Sofia; 1, Georgi Sofiiski Str., 1431 Sofia, Bulgaria; E-mail: a.mlachkova@fdm.mu-sofia.bg
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Received: 31 May 2022
Published online: 25 October 2022