head JofIMAB
Journal of IMAB - Annual Proceeding (Scientific Papers)
Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2022, vol. 28, issue4
Subject Area: Medicine
DOI: 10.5272/jimab.2022284.4731
Published online: 13 December 2022

Original article
J of IMAB. 2022 Oct-Dec;28(4):4731-4734
Tatyana Simeonova1ORCID logo Corresponding Autoremail, Krasimira Stefanova2ORCID logo, Pavlina Yordanova-Laleva3ORCID logo, Boryana Ruseva1ORCID logo, Aneliya Dimitrova1ORCID logo,
1) Department of Physiology and Pathophysiology, Medical University - Pleven, Bulgaria.
2) Diagnostic Consulting Center II - Pleven, Bulgaria.
3) Faculty of Pharmacy, Medical University-Pleven, Bulgaria.

Antiresorptive long-term treatment for osteoporosis increases bone mineral density. Due to the long duration, poor compliance of patients to medication therapy is a big challenge. Bone mineral density measurements are recommended for the monitoring of treatment, but detectable changes may take up to 2-3 years. Bone turnover markers can indicate changes in bone turnover rates earlier, and assessment their levels may be effective in enhancing compliance and clinical efficacy. 
Purpose: Our study aimed to assess whether the dynamics in serum levels of bone resorption marker beta-CrossLaps have a real practical benefit for early monitoring of postmenopausal osteoporosis treatment.
Materials and methods: 21 Bulgarian women in menopause with newly diagnosed osteoporosis were studied. All participants hadn’t been under treatment. Serum beta-CrossLaps levels were measured before and six months after subcutaneous administration of Denosumab – Injection 60 mg.
Results: Serum concentrations before and six months after starting treatment were respectively 0.589 ± 0.266 ng/ml (0.06 – 1.2) and 0.166 ± 0.139 ng/ml (0.05 – 0.59). The beta-CrossLaps pre-treatment serum levels were within the reference range for the commercial kit used. After six months of treatment, there was a significant decrease in serum concentrations of about 72% from baseline. In our study, although pre-treatment levels were within the reference range, a significant decrease in concentrations was observed.
Conclusions: The results show that the dynamics of beta-CrossLaps may be useful in the early monitoring of osteoporosis treatment.

Keywords: postmenopausal osteoporosis, early monitoring treatment, beta-CrossLaps, bone resorption markers, Denosumab,

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Please cite this article as: Simeonova T, Stefanova K, Yordanova-Laleva P, Ruseva B, Dimitrova A. Bone resorption marker Beta-CrossLaps for early monitoring of osteoporosis treatment with Denosumab. J of IMAB. 2022 Oct-Dec;28(4):4731-4734. DOI: 10.5272/jimab.2022284.4731

Corresponding AutorCorrespondence to: Tatyana N. Simeonova, Department of Physiology and Pathological Physiology, Medical University-Pleven; 1, St. Kliment Ohridski str., Pleven 5800, Bulgaria; E-mail: dr_tsimeonova@abv.bg

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Received: 10 June 2022
Published online: 13 December 2022

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