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Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2023, vol. 29, issue2
Subject Area: Medicine
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DOI: 10.5272/jimab.2023292.5009
Published online: 27 June 2023
Original article
J of IMAB. 2023 Apr-Jun;29(2):5009-5013
PERMANENT LOW NORMAL TESTOSTERONE LEVELS AND SEMINOLOGICAL DAMAGES IN MEN FROM 37 TO 45 YEARS OLD
Georgi Lazarov1, 2
, Vladislav Mladenov3,
1)Department Molecular Immunology, Institute of Biology and Immunology of Reproduction, Bulgarian Academy of Sciences, Sofia, Bulgaria.
2 ) Hospital in Obstetrics and Gynecology "St. Sofia ", Andrological office, Sofia, Bulgaria.
3) Department of Urology, UMBAL Alexandrovska, Medical University - Sofia, Bulgaria.
ABSTRACT:
In our practice, we are increasingly seeing men aged from 37 to 45 years' old who have permanent low normal testosterone levels.
Aim: We set out to investigate whether there is an association between permanent low normal testosterone levels and negative change in seminal fluid parameters in young men.
Patients and Methods: For the period from January 2013 to December 2015 at the Andrology office at Hospital "St. Sofia" we examined 73 men aged 37 to 45 years with normal or elevated body mass index, permanent low normal testosterone level, and negative change in seminal fluid parameters. In order to compare the results we obtained, at the very beginning of the study we selected a control group of 20 healthy men of the same age.
Results: We obtained, although within reference ranges, significantly lower values for total testosterone in the 73 men with negative change in seminal fluid parameters, compared with those in the control group without seminal damages (p<0.001) We found a high correlation relationship between the level of testosterone and the results of the first (r = 0.614, p<0.001) and second spermograms (r = 0.662, p<0.001).
Conclusions:
1. Our study shows that in a number of men at a young age, some decrease in normal testosteronе secretion occurs, with a concomitant negative change in seminal fluid parameters, which is remarkably different from the same parameters in their peers with a high normal testosterone level.
2. We identify permanent low normal testosterone, overweight and obesity as predictors, signaling a possible negative change in seminal fluid parameters.
3. We can say that if obesity plays some role in seminal damages, the mechanism in most cases is most likely related to the sustained permanent low normal testosterone level, as a result of increased adipose tissue.
Keywords: low normal testosterone, BMI, seminal damages,
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Please cite this article as: Lazarov G, Mladenov V. Permanent low normal testosterone levels and seminological damages in men from 37 to 45 years old. J of IMAB. 2023 Apr-Jun;29(2):5009-5013. [Crossref - 10.5272/jimab.2023292.5009]
Correspondence to: Georgi Lazarov, MD, Department of Molecular Immunology, Institute of Biology and Immunology of Reproduction, Bulgarian Academy of Sciences, Sofia; 73, Tzarigradsko shose Blvd., Sofia; Hospital in Obstetrics and Gynecology "St. Sofia ", Аndrological office; 2, Mihalaky Tashev Srt., Sofia, Bulgaria; E-mail: doctorlazarov30@gmail.com
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Received: 24 February 2023
Published online: 27 June 2023