A case report of complete androgen insensitivity syndrome rising a concern about the time of surgery and the role of parents’ behavior

Victoria Spasova; Liliya Koleva; Svetlana Shumarova; Diana Hristova; Ventsislava Pencheva; Anatoli Kolev; Bozhidar Karamishev; Daria Koleva; Vladislav Petkov; Svetozar Marangozov; Vesela Karamisheva

doi:10.5272/jimab.2024302.5505

Journal of IMAB
Publisher: Peytchinski Publishing Ltd.
ISSN: 1312-773X (Online)
Issue: 2024, vol. 30, issue2
Subject Area: Medicine
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DOI: 10.5272/jimab.2024302.5505
Published online: 09 May 2024

Case report
J of IMAB. 2024 Apr-Jun;30(2):5505-5508
A CASE REPORT OF COMPLETE ANDROGEN INSENSITIVITY SYNDROME RISING A CONCERN ABOUT THE TIME OF SURGERY AND THE ROLE OF PARENTS' BEHAVIOR
Victoria Spasova¹ , Liliya Koleva^{2, 3}, Svetlana Shumarova^{4, 5}, Diana Hristova^{5, 6}, Ventsislava Pencheva⁵, Anatoli Kolev⁴, Bozhidar Karamishev^{2, 3}, Daria Koleva⁴, Vladislav Petkov⁴, Svetozar Marangozov⁷, Vesela Karamisheva^{8, 9},
1)Department of Medical Genetics, Medical University of Sofia, Bulgaria.
2)Operative gynecology clinic UMBALSM "N. I. Pirogov", Sofia, Bulgaria.
3)University Hospital "Sofiamed", Sofia, Bulgaria.
4) Department of Surgery, Medical Faculty, Medical University of Sofia, Bulgaria.
5)University Hospital "Aleksandrovska", Medical University Sofia, Bulgaria.
6)National Center for Infectious and Parasitic Diseases, Sofia, Bulgaria.
7)Military Medical Academy, Sofia, Bulgaria.
8)Second gynecology clinic SBALAG "Maichin dom", Sofia, Bulgaria.
9)Department of Obstetrics and Gynecology, Medical University of Sofia, Bulgaria.

ABSTRACT:
Purpose: This case study refers to a case of complete androgen insensitivity syndrome, which presented with amenorrhea back in the past.
Case: After conformation of the diagnosis, parents decided not to reveal the condition’s specifics to the patient. At the age of 34 years, she attended our hospital with abdominal swelling, and the following CT scan showed an abdominal mass arising from the ovary of 13 cm x 14 cm size. A laparotomy was done, and a mixture of solid and cystic mass of 20 cm in diameter was found and removed with the ovary. Histopathology of the tumor showed features of testicular seminoma.
Conclusion: The aim of this case report is to outline the difficulties in choosing whether and when to do the gonadectomy and whether and how to explain the condition to the patient.

Keywords: androgen insensitivity syndrome, surgery, malignancy, disorders of sex development, psychology impact,

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Please cite this article as: Spasova V, Koleva L, Shumarova S, Hristova D, Pencheva V, Kolev A, Karamishev B, Koleva D, Petkov V, Marangozov S, Karamisheva V. A case report of complete androgen insensitivity syndrome rising a concern about the time of surgery and the role of parents’ behavior. J of IMAB. 2024 Apr-Jun;30(2):5505-5508. [Crossref - 10.5272/jimab.2024302.5505]

Correspondence to: Victoria Spasova, MD, Department of Medical Genetics, Medical faculty, Medical University of Sofia; 2, Zdrave Str, 1431 Sofia, Bulgaria; E-mail: vic.spasova@gmail.com

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Received: 20 November 2023
Published online: 09 May 2024

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